Case Report: Hemophagocytic lymphohistiocytosis masquerading as drug-induced liver injury: successful treatment with low-dose ruxolitinib and glucocorticoids - Report - MDSpire

Case Report: Hemophagocytic lymphohistiocytosis masquerading as drug-induced liver injury: successful treatment with low-dose ruxolitinib and glucocorticoids

  • By

  • Yang Dai

  • Luocheng Zhang

  • Xushu Zhong

  • Ailin Zhao

  • Ting Niu

  • May 28, 2026

  • 0 min

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Clinical Report: Hemophagocytic Lymphohistiocytosis Presenting as DILI

Overview

{'treatment_details': 'Include specific dosages and duration of ruxolitinib and corticosteroids.'}

Background

{'statistics': 'Add prevalence data or references to studies on HLH in DILI.'}

Data Highlights

{'patient_data': 'Ensure all relevant clinical data is presented.'}

Key Findings

{'genetic_variants': 'Detail the clinical significance of the identified genetic variants.'}

Clinical Implications

{'diagnostic_criteria': 'Suggest specific criteria for diagnosing HLH in DILI.'}

Conclusion

{'summary': 'Reiterate the importance of early diagnosis and summarize treatment outcomes.'}

Related Resources & Content

  1. Bone Marrow Transplantation, 2024 -- Incorporating Ruxolitinib into Standard Prophylaxis for Graft-Versus-Host Disease in Aplastic Anemia Patients Undergoing Allogeneic Stem Cell Transplantation
  2. Blood Cancer Journal, 2024 -- Efficacy of Emapalumab and Ruxolitinib in Treating Haemophagocytic Lymphohistiocytosis Patients
  3. the asco post, 2025 -- Use of Ruxolitinib to Resolve Ciltacabtagene Autoleucel–Induced Parkinsonism in Patients With Multiple Myeloma
  4. The ASCO Post, 2021 -- Ruxolitinib Granted FDA Approval for Chronic Graft-vs-Host Disease
  5. Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and HLH Across Speciality Collaboration (HiHASC) consensus guideline - PubMed
  6. Hemophagocytic Lymphohistiocytosis | New England Journal of Medicine
  7. Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and HLH Across Speciality Collaboration (HiHASC) consensus guideline - PubMed
  8. Hemophagocytic Lymphohistiocytosis | New England Journal of Medicine

Original Source(s)

Case Report: Hemophagocytic lymphohistiocytosis masquerading as drug-induced liver injury: successful treatment with low-dose ruxolitinib and glucocorticoids

  • by Yang Dai, Luocheng Zhang, Xushu Zhong, Ailin Zhao, Ting Niu

  • May 28, 2026

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