Association Between Metabolic Clusters and Microbial Age in High-Risk Populations for Diabetes and Their Potential Impact on Cardiovascular Disease Risk: Cross-Sectional Observational Study - Report - MDSpire

Association Between Metabolic Clusters and Microbial Age in High-Risk Populations for Diabetes and Their Potential Impact on Cardiovascular Disease Risk: Cross-Sectional Observational Study

  • By

  • Lu Xinlin

  • Hongli Gu

  • Ren Li

  • Xianjun Mao

  • Can Chen

  • May 26, 2026

  • 0 min

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Link Between Metabolic Profiles and Microbial Age in High-Risk Diabetes Populations

Overview

This study investigates the interrelationships between metabolic clusters and microbial age in high-risk diabetes populations.

Background

Diabetes affects approximately 463 million adults globally and is associated with severe complications, including cardiovascular disease (CVD). The interplay between metabolic disorders and gut microbiota is crucial for understanding disease progression in diabetes.

Data Highlights

No numerical data or trial data provided in the source material.

Key Findings

['Diabetes is characterized by chronic hyperglycemia and associated metabolic disorders.', 'The gut microbiota plays a significant role in host metabolism and is linked to metabolic disorders in diabetes.', 'Microbial age (MA) reflects the health status and metabolic function of the host.', 'Changes in gut microbiota composition are associated with the pathogenesis of diabetes and its complications.']

Clinical Implications

The study emphasizes the assessment of microbial age and metabolic profiles in high-risk diabetes populations.

Conclusion

The exploration of metabolic clusters and microbial age in diabetes populations is discussed.

Related Resources & Content

  1. International Diabetes Federation, IDF Diabetes Atlas, 2019 -- Global Diabetes Statistics
  2. American Diabetes Association, Standards of Care in Diabetes, 2026 -- Clinical Guidelines
  3. Nature Communications, 2026 -- Oral microbiome signatures predict biological age and host health
  4. European Journal of Preventive Cardiology — Cardiovascular Risk in Diabetes: An Ongoing Evolution
  5. European Journal of Preventive Cardiology — Variations in the Relationship Between Modifiable Lifestyle Risk Factors and New-Onset Cardiovascular Disease in Diabetic versus Non-Diabetic Individuals
  6. The Journal of Clinical Endocrinology & Metabolism — The Role of Adipokines in Changes in Metabolic Health Over Time: Insights from the Atherosclerosis Risk in Communities (ARIC) Study
  7. The Journal of Clinical Endocrinology & Metabolism — Long-Term Insulin Exposure During Childhood and Adulthood and Its Impact on Retinal Microvasculature in Adulthood
  8. European Journal of Preventive Cardiology — Cardiovascular Risk in Diabetes: An Ongoing Evolution
  9. European Journal of Preventive Cardiology — Variations in the Relationship Between Modifiable Lifestyle Risk Factors and New-Onset Cardiovascular Disease in Diabetic versus Non-Diabetic Individuals
  10. The Journal of Clinical Endocrinology & Metabolism — The Role of Adipokines in Changes in Metabolic Health Over Time
  11. Standards of Care in Diabetes | ADA Clinical Guidelines
  12. Oral microbiome signatures predict biological age and host health | Nature Communications

Original Source(s)

Association Between Metabolic Clusters and Microbial Age in High-Risk Populations for Diabetes and Their Potential Impact on Cardiovascular Disease Risk: Cross-Sectional Observational Study

  • by Lu Xinlin, Hongli Gu, Ren Li, Xianjun Mao, Can Chen

  • May 26, 2026

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