Survival without major morbidity in extremely preterm infants: a prospective multicenter study in Shenzhen, China - Report - MDSpire

Survival without major morbidity in extremely preterm infants: a prospective multicenter study in Shenzhen, China

  • By

  • Yanping Guo

  • Ying Liu

  • Hua Peng

  • Songzhou Xu

  • Xudong Yan

  • Zhangbin Yu

  • Guobing Chen

  • July 8, 2026

  • 0 min

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Outcomes of Extremely Preterm Infants: A Prospective Multicenter Analysis

Overview

This study evaluates the survival rates and major morbidities of extremely preterm infants (EPIs) in Shenzhen, China.

Background

Extremely preterm infants (EPIs) face high risks of mortality and severe morbidity, including long-term neurodevelopmental impairments. Despite advancements in neonatal care, outcomes for EPIs can vary significantly across regions.

Data Highlights

OutcomeValue
Overall survival rate74.52% (234/314)
Survival without major morbidity24.20% (76/314)
Moderate-to-severe bronchopulmonary dysplasia48.72% (114/234)
Severe intraventricular hemorrhage/periventricular leukomalacia13.25% (31/234)
Necrotizing enterocolitis stage ≥ 26.41% (15/234)
Sepsis22.65% (53/234)
Severe retinopathy of prematurity42.31% (99/234)

Key Findings

  • Overall survival rate of EPIs was 74.52%.
  • Only 24.20% of infants survived without major morbidity.
  • Major morbidities included bronchopulmonary dysplasia (48.72%) and severe retinopathy of prematurity (42.31%).
  • Antenatal corticosteroid use was associated with improved survival without major morbidity (OR = 7.66).
  • Increasing gestational age and higher birth weight were also protective factors for survival without major morbidity.

Clinical Implications

The findings indicate associations between antenatal corticosteroid administration, gestational age, and birth weight with survival outcomes.

Conclusion

This study provides data on the survival and morbidity outcomes of EPIs in Shenzhen.

Related Resources & Content

  1. Frontiers in Pediatrics, 2026 -- Neurodevelopmental outcomes in adolescents born very and extremely preterm: a prolonged follow-up from a single-center cohort
  2. Frontiers in Pediatrics, 2026 -- Determinants of growth parameters at 12-month corrected age among very preterm infants in China: a retrospective cohort study
  3. BMJ Paediatrics Open, 2023 -- Healthcare burden of bronchopulmonary dysplasia among very preterm infants in China: a cohort study
  4. Frontiers in Pediatrics — Association of individual and bundled evidence-based practices with adverse outcomes in very preterm infants: a multicenter retrospective study
  5. Neonatal Resuscitation Guidelines
  6. Kangaroo mother care: a clinical practice guide
  7. Neonatal Task Force – 2025 Evidence Updates
  8. Cochrane Library Cochrane Database of Systematic R
  9. Outcomes of Preterm Infants Born at 22 to 23 Weeks’ Gestation
  10. Survival of Infants Born at 22 to 25 Weeks’ Gestation Receiving Care in the NICU: 2020–2022 | Pediatrics | American Academy of Pediatrics
  11. Global inequities in the survival of extremely preterm infants: a systematic review and meta-analysis - PMC
  12. [Outcomes and care practices of extremely preterm infants at 22-25 weeks' gestation age from the Chinese Neonatal Network]. | CoLab
  13. Ventilatory Assistance Before Umbilical Cord Clamping in Extremely Preterm Infants: A Randomized Clinical Trial
  14. Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm Infants: The PLUSS Randomized Clinical Trial - PMC
  15. Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen - PubMed
  16. Less Invasive Surfactant Administration in Extreme Preterm Infants: A Systematic Review and Meta-Analysis | Neonatology | Karger Publishers

Original Source(s)

Survival without major morbidity in extremely preterm infants: a prospective multicenter study in Shenzhen, China

  • by Yanping Guo, Ying Liu, Hua Peng, Songzhou Xu, Xudong Yan, Zhangbin Yu, Guobing Chen

  • July 8, 2026

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