Risk factors and postoperative complications following revision total knee arthroplasty in patients with metabolic syndrome–associated osteoarthritis: a 10-year retrospective analysis using a national inpatient database - Report - MDSpire

Postoperative Outcomes and Risk Factors in Revision Total Knee Arthroplasty for Patients with Osteoarthritis Linked to Metabolic Syndrome: A Decade-Long Retrospective Study Utilizing a National Inpatient Database

  • By

  • Miaolan Yuan

  • Hao Xie

  • Yanjie He

  • Yinyin Qin

  • Jian Wang

  • July 20, 2026

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Clinical Report: Postoperative Outcomes in Revision Total Knee Arthroplasty

Overview

This study examines the increasing prevalence of metabolic syndrome-associated osteoarthritis (MetS-OA) among patients undergoing revision total knee arthroplasty (RTKA) and identifies associated risk factors.

Background

Osteoarthritis (OA) is a prevalent degenerative joint disorder, particularly among older adults. Metabolic syndrome-associated osteoarthritis (MetS-OA) has emerged as a significant clinical phenotype, with its prevalence rising in parallel with the aging population and increasing obesity rates.

Data Highlights

MetricValue
Prevalence of MetS-OA16.1%
Increased hospitalization charges$1,445.50
Postoperative complicationsHigher likelihood compared to non-MetS-OA

Key Findings

  • The prevalence of MetS-OA among RTKA patients increased from 2011 to 2019.
  • Independent risk factors for MetS-OA include advanced age, male sex, non-White racial background, and comorbid conditions.
  • Patients with MetS-OA had longer hospital stays and higher hospitalization charges.
  • In-hospital mortality rates were similar between patients with and without MetS-OA.
  • MetS-OA was associated with a higher incidence of postoperative complications.

Clinical Implications

Healthcare providers should be aware of the increasing prevalence of MetS-OA and its associated risks when planning for RTKA.

Conclusion

The study highlights the growing impact of MetS-OA on RTKA outcomes.

Related Resources & Content

  1. Archives of Orthopaedic and Trauma Surgery, 2026 -- Preoperative lower radiographic osteoarthritis severity in primary total knee arthroplasty increases revision risk by tenfold compared to severe osteoarthritis
  2. Archives of Orthopaedic and Trauma Surgery, 2019 -- Evaluating Total Knee Arthroplasty Results in Patients with Severe Obesity: A Comprehensive Literature Review
  3. Archives of Orthopaedic and Trauma Surgery, 2024 -- Evaluating the Risks of Perioperative Complications Following Aseptic Knee Revision Surgery
  4. Archives of Orthopaedic and Trauma Surgery, 2025 -- Influence of the Charlson Comorbidity Index, ethnicity, and surgical complications on postoperative outcomes following total knee arthroplasty
  5. Journal of Orthopaedic Research, 2026 -- The 2025 International Consensus Meeting on Musculoskeletal Infection: Research Priorities and Future Directions
  6. PubMed, 2023 -- Increased Risk of Postoperative Complications Following Total Knee Arthroplasty in Patients Who Have Metabolic Syndrome
  7. The Journal of Arthroplasty, 2025 -- Etiology of Failure in Revision Total Knee Arthroplasty: A Systematic Review and Meta-Analysis
  8. The 2025 International Consensus Meeting on Musculoskeletal Infection: Research Priorities and Future Directions - Oral - 2026 - Journal of Orthopaedic Research - Wiley Online Library
  9. Increased Risk of Postoperative Complications Following Total Knee Arthroplasty in Patients Who Have Metabolic Syndrome - PubMed
  10. Etiology of Failure in Revision Total Knee Arthroplasty: A Systematic Review and Meta-Analysis - The Journal of Arthroplasty

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