Comparative effectiveness of aerobic training intensities in chronic stroke: a network meta-analysis of randomized controlled trials - Report - MDSpire

Comparative effectiveness of aerobic training intensities in chronic stroke: a network meta-analysis of randomized controlled trials

  • By

  • Qiu Peng

  • Yidong Xia

  • Haoyuan Hei

  • July 6, 2026

  • 0 min

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Clinical Report: Effectiveness Comparison of Aerobic Exercise Intensities in Chronic Stroke Patients

Overview

This study conducts a network meta-analysis of 33 RCTs to evaluate the effects of aerobic exercise modalities on cardiopulmonary fitness and functional recovery in chronic stroke patients. High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) showed significant improvements in VO2peak and walking performance. Evidence certainty was assessed as predominantly low to very low across comparisons.

Background

Stroke is a leading cause of death and disability globally, with many survivors facing significant motor impairments that hinder physical activity. Regular aerobic exercise is essential for improving cardiovascular fitness and functional recovery in stroke patients.

Data Highlights

OutcomeInterventionEffect Size
VO2peakHIIT, MICTEffect sizes varied
6MWTHIIT, MICTEffect sizes varied
10MWTHIIT, MICTEffect sizes varied
BBSVarious interventionsNo significant differences
TUGVarious interventionsNo significant differences

Key Findings

  • HIIT and MICT showed the most significant effects on VO2peak, 6MWT, and 10MWT.
  • No statistically significant differences were found for BBS or TUG among most interventions.
  • Evidence certainty was predominantly low to very low across comparisons, particularly for BBS and TUG.
  • 33 RCTs with 1,665 participants were included in the analysis.

Clinical Implications

Clinicians should consider incorporating HIIT and MICT into rehabilitation programs for chronic stroke patients to enhance cardiopulmonary fitness and walking ability. However, the low certainty of evidence necessitates cautious interpretation of these findings.

Conclusion

HIIT and MICT may improve fitness and walking performance in chronic stroke patients, but the overall evidence quality is low.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Effectiveness of different types of exercise therapy in improving post-stroke depression: a systematic review and network meta-analysis
  2. Frontiers in Neurology, 2026 -- High-intensity interval training after stroke: a three-level random-effects meta-analysis with cluster-robust inference and exploratory dose-parameter signals
  3. Frontiers in Neurology, 2026 -- A systematic review and meta-analysis of the effects of exercise training on dysfunction in acute, subacute, and chronic stroke patients
  4. BPR08 Introduction, 2025 -- Canadian Stroke Best Practice Recommendations
  5. VA DoD CPG for Management of Stroke Rehabilitation, 2024
  6. Frontiers in Neurology — Comparison of the effects of different traditional Chinese exercises on improving the motor function of stroke survivors: a network meta-analysis and systematic review
  7. 2025 Canadian Stroke Best Practice Recommendations
  8. 2024 VA/DoD Clinical Practice Guideline for Management of Stroke Rehabilitation
  9. Frontiers | Effects of high-intensity interval training versus moderate-intensity continuous training on cardiorespiratory function in patients after stroke: a systematic review and meta-analysis of randomized trials

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