Impact of frailty on 12-month patient-reported outcomes after posterior lumbar fusion surgery - Report - MDSpire

Impact of frailty on 12-month patient-reported outcomes after posterior lumbar fusion surgery

  • By

  • Henryk Haffer

  • Maximilian Muellner

  • Erika Chiapparelli

  • Yusuke Dodo

  • Gaston Camino-Willhuber

  • Jiaqi Zhu

  • Matthias Pumberger

  • Jennifer Shue

  • Andrew A. Sama

  • Frank P. Cammisa

  • Federico P. Girardi

  • Alexander P. Hughes

  • May 12, 2026

  • 0 min

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Clinical Report: Influence of Frailty on Patient-Reported Outcomes at 12 Months Following Posterior Lumbar Fusion Surgery

Overview

This study evaluates the impact of frailty, as measured by the modified 5-Item Frailty Index (mFI-5), on patient-reported outcomes (PROs) at 12 months post-lumbar fusion surgery. Findings indicate that frailty significantly affects functional outcomes, highlighting the need for frailty assessment in surgical risk stratification.

Background

Frailty is associated with increased vulnerability to adverse health outcomes following surgery, particularly in older adults. As the population ages and the incidence of degenerative spine disorders rises, understanding the role of frailty in surgical outcomes becomes critical. This study aims to clarify how frailty influences patient-reported outcomes after lumbar spinal fusion, a common procedure in this demographic.

Data Highlights

Outcome MeasureFollow-Up Time Points
Oswestry Disability Index (ODI)12 Months
Short Form Healthy Survey (SF-12) - Physical Component Score (PCS-12)6 Weeks, 3 Months, 6 Months, 12 Months
Short Form Healthy Survey (SF-12) - Mental Component Score (MCS-12)6 Weeks, 3 Months, 6 Months, 12 Months
NRS for Back Pain (NRS-B)6 Weeks, 3 Months, 6 Months, 12 Months
NRS for Leg Pain (NRS-L)6 Weeks, 3 Months, 6 Months, 12 Months

Key Findings

  • Frailty, as assessed by the mFI-5, is a significant predictor of functional outcomes post-lumbar fusion.
  • Patients with higher frailty scores reported poorer outcomes on the Oswestry Disability Index at 12 months.
  • Frailty status influenced both physical and mental health component scores on the SF-12.
  • Higher frailty levels correlated with increased pain scores (NRS-B and NRS-L) at follow-up.
  • Patients achieving substantial clinical benefit at 12 months were fewer among those classified as frail.

Clinical Implications

Healthcare providers should incorporate frailty assessments into preoperative evaluations for lumbar fusion surgery. Understanding a patient's frailty status can guide surgical decision-making and postoperative care strategies to optimize outcomes.

Conclusion

The findings underscore the importance of frailty as a determinant of patient-reported outcomes following lumbar fusion surgery, advocating for its routine assessment in clinical practice.

Related Resources & Content

  1. Iqbal et al., Influence of Frailty on Patient-Reported Outcomes, 2023 -- Influence of Frailty on Patient-Reported Outcomes at 12 Months Following Posterior Lumbar Fusion Surgery
  2. Outcomes of Lumbar Spinal Fusion Surgery for Degenerative Spondylolisthesis, 2020 -- Outcomes of Lumbar Spinal Fusion Surgery for Degenerative Spondylolisthesis: Results from a Three-Year Follow-Up Study
  3. Lumbar Degenerative Disc Disease, 2023 -- Lumbar Degenerative Disc Disease with Positive SPECT/CT Findings: Insights from the SPINUS I Trial on Single-Level Spinal Fusion
  4. Postoperative Complications Following Lumbar Spinal Stenosis Surgery, 2024 -- Evaluation of Postoperative Complications Following Lumbar Spinal Stenosis Surgery Utilizing Two Distinct Data Sources
  5. American College of Surgeons, 2025 -- American College of Surgeons’ 2026 Quality Verification Program standards
  6. Journal of Neuro-Oncology — The Evolving Characteristics of Frailty in Patients with Metastatic Spine Disease
  7. American College of Surgeons - Standards for Quality Verification Program
  8. Influence of Frailty on Clinical and Radiological Outcomes in Patients Undergoing Transforaminal Lumbar Interbody Fusion—Analysis of a Controlled Cohort of 408 Patients - PMC
  9. Major outcomes from PEEDS in multilevel deformity surgery

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