RNF213 marks a regulatory T-cell subset associated with ulcerative colitis - Report - MDSpire

RNF213 marks a regulatory T-cell subset associated with ulcerative colitis

  • By

  • Zhangqin Li

  • Jing Wu

  • Jiayi Yang

  • Lianyu Zhou

  • Lifang Chen

  • Youxu Ren

  • Yunxing Li

  • Ruijie Ma

  • Yinglei Miao

  • Jie Jia

  • Jiarong Miao

  • July 6, 2026

  • 0 min

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Clinical Report: RNF213 Identifies a Regulatory T-Cell Subpopulation Linked to Ulcerative Colitis

Overview

This study identifies RNF213 as a biomarker enriched in mucosal Tregs associated with ulcerative colitis (UC). RNF213+ Tregs exhibit distinct transcriptional programs and increased presence in UC patients compared to healthy controls.

Background

Ulcerative colitis is a chronic autoimmune disease characterized by inflammation of the intestinal tract. Understanding the mechanisms underlying UC is crucial for developing targeted therapies.

Data Highlights

BiomarkerAUC
RNF213Greater than 0.9

Key Findings

  • Five UC-specific ubiquitination biomarkers were identified: ZC3H12A, ENC1, RNF213, MAP3K5, and RMND5A.
  • RNF213 demonstrated superior diagnostic performance with an AUC greater than 0.9 in both training and validation cohorts.
  • RNF213 was enriched in mucosal Tregs from UC patients compared to healthy controls.
  • In-silico analysis suggested RNF213+ Tregs are associated with mitochondrial proton transport and ATP synthesis.
  • CellChat analysis predicted altered ligand-receptor interactions among RNF213+ Tregs and other immune cells.

Clinical Implications

The identification of RNF213 in UC-associated Tregs may assist in the development of targeted therapies.

Conclusion

RNF213 is a biomarker linked to a distinct Treg subset associated with inflammatory processes in UC.

Related Resources & Content

  1. Frontiers | The RNF213 marks a regulatory T-cell subset associated with Ulcerative colitis
  2. Journal of Crohn's and Colitis — IL23R-Specific CAR Tregs for the Treatment of Crohn’s Disease
  3. Frontiers in Immunology — CD38+ NK cells: novel players in immunoregulation
  4. Frontiers in Immunology — IL21 is predominantly produced by a CXCL13 associated CD4+ T cell subset and shapes the immune microenvironment in colorectal cancer
  5. Journal of Gastroenterology — Significance of the IL-22 Pathway in Inflammatory Bowel Disease
  6. ACG Clinical Guideline: Management of Ulcerative Colitis Disease in Adults
  7. Anti-TL1A antibody, afimkibart, in moderately-to-severely active ulcerative colitis (TUSCANY-2)
  8. Frontiers | The RNF213 marks a regulatory T-cell subset associated with Ulcerative colitis

Original Source(s)

RNF213 marks a regulatory T-cell subset associated with ulcerative colitis

  • by Zhangqin Li, Jing Wu, Jiayi Yang, Lianyu Zhou, Lifang Chen, Youxu Ren, Yunxing Li, Ruijie Ma, Yinglei Miao, Jie Jia, Jiarong Miao

  • July 6, 2026

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