Remimazolam-based anesthesia in sepsis patients: a retrospective cohort study of hemodynamic stability and postoperative outcomes - Report - MDSpire

Remimazolam-based anesthesia in sepsis patients: a retrospective cohort study of hemodynamic stability and postoperative outcomes

  • By

  • Hyunyoung Seong

  • Sejong Jin

  • Yeon Jae Song

  • Woohyun Park

  • Hyun Ah Lee

  • Jang Eun Cho

  • July 1, 2026

  • 0 min

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Clinical Report: Evaluation of Remimazolam Anesthesia in Patients with Sepsis

Overview

This study evaluates remimazolam-based anesthesia in septic patients undergoing urgent abdominal surgery.

Background

Abdominal sepsis is a critical surgical emergency linked to high morbidity and mortality rates. Patients often experience hemodynamic instability during surgery, making anesthetic management crucial.

Data Highlights

OutcomeGroup R (Remimazolam)Group C (Propofol)P-value
VIS at ICU admissionLowerHigher0.006
ICU Length of StayShorterLonger0.008
Hospital Length of StayShorterLonger0.012
In-hospital MortalityLowerHigher0.007
Hospital-acquired InfectionsFewerMore0.048

Key Findings

  • Remimazolam resulted in a lower Vasopressor-Inotrope Score at ICU admission compared to propofol.
  • Patients receiving remimazolam had shorter ICU and hospital lengths of stay.
  • In-hospital mortality was significantly lower in the remimazolam group.
  • Fewer hospital-acquired infections were observed in patients anesthetized with remimazolam.

Clinical Implications

The findings suggest that remimazolam may be an alternative to traditional anesthetics in this population.

Conclusion

Remimazolam-based anesthesia was associated with greater hemodynamic stability and reduced postoperative vasopressor needs.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Clinical outcomes of a remimazolam-based sedation regimen in patients receiving ECMO: a retrospective comparative study
  2. Frontiers in Medicine, 2026 -- The delirium dichotomy of remimazolam: a differential risk profile for emergence delirium versus postoperative delirium in surgical patients: a systematic review and meta-analysis
  3. Frontiers in Medicine, 2026 -- Remimazolam Is Associated with Superior Cerebral and Pulmonary Protection over Propofol in Elderly Thoracic Surgery: A Real-World Study Validated by Propensity Score Matching
  4. Frontiers in Medicine, 2026 -- Commentary: Safety and efficacy of remimazolam versus propofol sedation in gynecological procedures: a meta-analysis of East Asian randomized trials
  5. Surviving Sepsis Campaign Adult Guidelines | SCCM
  6. Effect of remimazolam versus propofol on hypotension after anesthetic induction in patients undergoing coronary artery bypass grafting: A randomized controlled trial - ScienceDirect
  7. Surviving Sepsis Campaign Adult Guidelines | SCCM
  8. Effect of remimazolam versus propofol on hypotension after anesthetic induction in patients undergoing coronary artery bypass grafting: A randomized controlled trial - ScienceDirect

Original Source(s)

Remimazolam-based anesthesia in sepsis patients: a retrospective cohort study of hemodynamic stability and postoperative outcomes

  • by Hyunyoung Seong, Sejong Jin, Yeon Jae Song, Woohyun Park, Hyun Ah Lee, Jang Eun Cho

  • July 1, 2026

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