Initial Clinical Experience with NeVa NET Stent-Retriever in 20 Stroke Cases

Overview

This retrospective analysis of 20 patients treated with the NeVa NET stent-retriever demonstrated promising initial results in mechanical thrombectomy for large vessel occlusion strokes. The device’s unique dual-layered nitinol NET design aims to reduce distal microembolisation and improve first pass effect, with early data supporting its safety and efficacy.

Background

Mechanical thrombectomy (MT) has evolved significantly since 2015, with improvements in catheter and stent-retriever designs enhancing recanalization outcomes. The NeVa NET stent-retriever introduces a novel distal protection mechanism via a dual-layered nitinol NET to capture microemboli during clot retrieval. This device aims to optimize reperfusion by preventing distal embolisation and increasing the first pass effect (FPE). The current study reports initial clinical experience using the NeVa NET as first-line therapy in two high-volume comprehensive stroke centers.

Data Highlights

Key Findings

• The NeVa NET device incorporates a dual-layered nitinol braid designed to capture microemboli smaller than 400 microns, potentially reducing distal embolisation during thrombectomy.
• In 20 patients treated as first-line with the NeVa NET, the median NIHSS was 18, indicating moderate to severe stroke severity.
• 30% of patients received intravenous tPA prior to thrombectomy, consistent with standard acute stroke protocols.
• Left-sided large vessel occlusions were more common (60%) in this cohort, with 10% presenting with tandem lesions.
• The device’s radial force is comparable to the widely used Solitaire 6 × 30 mm stent, suggesting similar mechanical performance.
• Initial procedural success was defined by achieving eTICI ≥ 2b recanalization, with first pass effect and modified first pass effect as key outcome measures.

Clinical Implications

The NeVa NET stent-retriever offers a promising new option for mechanical thrombectomy by targeting microembolisation, a known contributor to poor reperfusion outcomes. Its compatibility with standard microcatheters and comparable radial force to established devices facilitates integration into existing workflows. Early clinical use suggests it can be safely deployed as first-line therapy in patients with moderate to severe large vessel occlusion strokes.

Conclusion

Initial findings from two high-volume centers indicate that the NeVa NET stent-retriever is a feasible and potentially advantageous device for mechanical thrombectomy, warranting further study to confirm its impact on clinical and angiographic outcomes.

References

1. Vesalio/NeVa NET Device/2024 -- Initial Findings from 20 Cases Utilizing the NeVa Net Stent-Retriever