Linking Stages of Cardiovascular-Kidney-Metabolic Syndrome to All-Cause Mortality Risk in U.S. Adults: Findings from a NHANES Cross-Sectional Analysis - Report - MDSpire

Linking Stages of Cardiovascular-Kidney-Metabolic Syndrome to All-Cause Mortality Risk in U.S. Adults: Findings from a NHANES Cross-Sectional Analysis

  • By

  • Yuanze Du

  • Wenxue Sun

  • Jiaqi Zhang

  • Jinfeng Wang

  • Kai Deng

  • Xiaowei Qiao

  • Jie Zhang

  • Xiaofang Zhang

  • Yueyuan Li

  • Xinyu Zhang

  • Xin Yang

  • Fangyu Cheng

  • Zongshuai Wang

  • Chunping Wang

  • March 4, 2026

  • 0 min

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Linking Stages of Cardiovascular-Kidney-Metabolic Syndrome to All-Cause Mortality Risk

Overview

This study investigates the relationship between stages of Cardiovascular-Kidney-Metabolic (CKM) syndrome and all-cause mortality risk in U.S. adults. Findings indicate that higher CKM stages correlate with increased mortality risk, emphasizing the need for early intervention and management.

Background

The American Heart Association has defined CKM syndrome as a systemic disorder that integrates obesity, chronic kidney disease, diabetes, and cardiovascular conditions. Understanding CKM syndrome is crucial due to its rising prevalence and significant impact on healthcare costs and patient outcomes. This study aims to clarify the relationship between CKM stages and mortality, addressing a critical gap in current research.

Data Highlights

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Key Findings

  • CKM syndrome is classified into five stages, reflecting the severity of the disease.
  • Approximately 90.8% of U.S. adults were affected by CKM between 2011 and 2022.
  • 15% of U.S. adults are classified as having advanced CKD (stage 3 or 4).
  • Higher CKM stages are associated with reduced life expectancy.
  • CKM-related medical expenditures account for over 75% of total healthcare costs in the U.S.

Clinical Implications

Healthcare professionals should be aware of the significant mortality risk associated with advanced CKM stages. Early identification and management of CKM syndrome can potentially improve patient outcomes and reduce healthcare costs.

Conclusion

The study underscores the importance of recognizing CKM syndrome stages in clinical practice to mitigate mortality risk. Further research is needed to explore effective interventions for patients at higher CKM stages.

References

  1. American Heart Association, 2023 -- Linking Stages of Cardiovascular-Kidney-Metabolic Syndrome to All-Cause Mortality Risk
  2. European Journal of Preventive Cardiology, 2023 -- Cardiovascular–kidney–metabolic syndrome and mortality in a prospective UK cohort study
  3. Clinical Research in Cardiology, 2022 -- The Frequency and Prognostic Significance of Chronic Kidney Disease and Anemia in Different Stages of Heart Failure According to ACC/AHA Guidelines
  4. CKD Evaluation and Management – KDIGO, 2024
  5. Link Between Kidney Stones and Essential Life Factors: A Study Based on Population Data
  6. The Journal of Clinical Endocrinology & Metabolism — Age-Related Variations in the Relationship Between Systemic Inflammatory Response and Metabolic Syndrome
  7. Heart disease risk, prevention and management redefined
  8. CKD Evaluation and Management – KDIGO

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