Efficacy of acupuncture-based traditional Chinese medicine therapies for chronic fatigue syndrome: a systematic review and meta-analysis - Report - MDSpire

Efficacy of acupuncture-based traditional Chinese medicine therapies for chronic fatigue syndrome: a systematic review and meta-analysis

  • By

  • Yanbing Li

  • Gaozhe Liang

  • Tingting Xiao

  • Lei Xu

  • June 24, 2026

  • 0 min

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Clinical Report: Effectiveness of Traditional Chinese Medicine Acupuncture Treatments for Chronic Fatigue Syndrome

Overview

This systematic review and meta-analysis evaluated the efficacy of acupuncture-related therapies for chronic fatigue syndrome (CFS). Results indicated that acupuncture may significantly improve overall, physical, and mental fatigue.

Background

Chronic fatigue syndrome (CFS) is a complex condition characterized by persistent fatigue and other debilitating symptoms, affecting patients' quality of life and functional capacity. The lack of specific biomarkers complicates diagnosis and treatment, making effective management strategies critical. Acupuncture has emerged as a potential therapeutic option, warranting systematic evaluation of its effectiveness.

Data Highlights

OutcomeStandardized Mean Difference (SMD)95% Confidence Interval (CI)p-value
Overall Fatigue-1.31-2.16 to -0.470.002
Physical Fatigue-0.52-0.88 to -0.160.0048
Mental Fatigue-0.59-0.93 to -0.260.0006
Total Response Rate1.221.07 to 1.400.004
Adverse Events2.260.76 to 6.760.144

Key Findings

  • Eight RCTs with 715 patients were included in the review.
  • Acupuncture therapies significantly improved overall fatigue compared to control interventions.
  • Physical fatigue showed significant improvement with acupuncture (SMD = -0.52).
  • Mental fatigue also improved significantly (SMD = -0.59).
  • The total response rate was higher in the acupuncture group (RR = 1.22).
  • No significant difference in adverse events between groups was observed.

Clinical Implications

Clinicians should consider the limitations of the current evidence, including the risk of bias and heterogeneity among studies.

Conclusion

Acupuncture-related therapies may have some effects for patients with chronic fatigue syndrome, but further high-quality research is necessary to confirm these findings.

Related Resources & Content

  1. Frontiers in Oncology, 2026 -- Effectiveness of acupuncture for cancer-related fatigue: a systematic reviews and meta-analysis
  2. Frontiers in Neurology, 2026 -- A network meta-analysis of the performance of acupoint stimulation therapy in improving fatigue, neurological function, and activities of daily living in patients with multiple sclerosis
  3. Frontiers in Psychiatry, 2026 -- The efficacy of acupuncture for depression-associated chronic pain: a systematic review and meta-analysis
  4. About ME/CFS | National Institutes of Health (NIH), 2025
  5. Comparing different acupuncture methods for the treatment of chronic fatigue syndrome: A systematic review and network meta-analysis, 2025
  6. Frontiers in Psychiatry — Response: Commentary: Cognitive behavioural therapy for the treatment of chronic fatigue syndrome in adults: a short analysis of the meta-analysis
  7. About ME/CFS | National Institutes of Health (NIH)
  8. Comparing different acupuncture methods for the treatment of chronic fatigue syndrome: A systematic review and network meta-analysis - ScienceDirect
  9. Tuina therapy for patients with chronic fatigue syndrome: a randomized controlled trial | Journal of Translational Medicine | Springer Nature Link

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