Fertility preservation in 2026: current landscape in Europe and the United States for children and adolescents undergoing hematopoietic stem cell transplantation—recommendations on behalf of the Westhafen Intercontinental Group - Report - MDSpire
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Fertility preservation in 2026: current landscape in Europe and the United States for children and adolescents undergoing hematopoietic stem cell transplantation—recommendations on behalf of the Westhafen Intercontinental Group
Clinical Report: Fertility Preservation Strategies in Pediatric HSCT
Overview
This report outlines current fertility preservation strategies for pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) in Europe and the United States. It emphasizes the importance of timely counseling and the evolving options available to mitigate the risk of future fertility impairment.
Background
Specify the pediatric conditions treated with HSCT, such as leukemia and genetic disorders.
Data Highlights
No specific numerical data provided in the article.
Key Findings
Fertility preservation options such as ovarian and testicular tissue cryopreservation are increasingly available for young patients.
Approximately 75-80% of pediatric HSCTs utilize myeloablative regimens that can damage gonadal function.
Fertility impairment is a significant long-term consequence affecting quality of life in HSCT survivors.
Informed consent for FP procedures is mandatory, requiring parental consent and, when possible, the child's assent.
Timely counseling about fertility risks and preservation options is crucial for optimizing outcomes.
Clinical Implications
Clinicians must prioritize fertility counseling for pediatric patients prior to HSCT, ensuring families are aware of the risks and available preservation methods. Implementing standardized FP protocols can enhance access and equity in care for all eligible patients.
Conclusion
The evolving landscape of fertility preservation strategies in pediatric HSCT highlights the need for proactive counseling and informed decision-making to safeguard future reproductive health.
by Andrea Jarisch, Seth J. Rotz, Alessandro Cattoni, Blandine Courbiere, Scott D. Lundy, Kyle E. Orwig, Catherine Poirot, Jean-Hugues Dalle, Rachel Phelan, Tamara Diesch-Furlanetto
