Street-Based Hepatitis C Treatment and Patient Experiences Among Adults Experiencing Unsheltered Homelessness - Report - MDSpire

Hepatitis C Management in Street Settings: Insights from Adults Facing Unsheltered Homelessness

  • By

  • Alizée Natsoulis

  • Claire Nussbaum

  • Lauren Howard

  • Daphne Achilles

  • Korrinne Yurick

  • Camilo Zaks

  • Alexis Coulourides Kogan

  • July 16, 2026

Share

Hepatitis C Management in Street Settings: Insights from Adults Facing Unsheltered Homelessness

Overview

This study explores the perspectives of patients engaged in street-based treatment for Hepatitis C (HCV) and assesses treatment outcomes. It highlights the challenges faced by individuals experiencing unsheltered homelessness in accessing HCV care.

Background

Hepatitis C virus (HCV) is a significant cause of chronic liver disease in the US, with a disproportionately high prevalence among individuals experiencing homelessness. Barriers to HCV care for this population include limited knowledge, lack of longitudinal care, and competing survival priorities.

Data Highlights

No numerical data or trial data was provided in the source material.

Key Findings

  • Approximately 1% of the general population is HCV-RNA positive, while prevalence among people experiencing homelessness ranges from 10% to 53%.
  • In Los Angeles, a study found a 27% HCV positivity rate among adults experiencing homelessness, with nearly half unaware of their infection.
  • Barriers to HCV care include limited knowledge of transmission and treatment, lack of longitudinal care, and competing survival priorities.
  • Street medicine models provide full spectrum primary care directly to individuals in their environment, potentially reducing barriers to care.
  • Direct-acting antivirals (DAAs) have shown high cure rates in sheltered homeless populations, but linkage to care remains a challenge for unsheltered individuals.

Clinical Implications

Healthcare providers should consider the unique barriers faced by individuals experiencing unsheltered homelessness when developing treatment plans for HCV. The street medicine model may serve as an effective approach to improve access to care and treatment outcomes for this marginalized population.

Conclusion

The study underscores the need for innovative care models to address the HCV treatment gap among unsheltered homeless individuals. Further research is warranted to evaluate the effectiveness of these approaches.

Related Resources & Content

  1. USC Street Medicine, Open Forum Infectious Diseases, 2023 -- Hepatitis C Management in Street Settings
  2. JAMA Network Open, 2023 -- Long-Acting Antiretroviral Therapy for HIV via Drop-in Community-Based Care
  3. Open Forum Infectious Diseases, 2023 -- Initiating Hepatitis C Treatment During Hospital Stays for Individuals Who Use Drugs
  4. Journal of General Internal Medicine (Springer) — Experiences of Adults Managing Cardiovascular Health While in Permanent Supportive Housing (PSH): A Qualitative Study
  5. AASLD/IDSA 2023 Clinical Practice Guidance Update for Testing, Managing, and Treating Hepatitis C Virus Infection
  6. Hepatitis C - WHO Fact Sheet
  7. FDA Permits Marketing of First Point-of-Care Hepatitis C RNA Test
  8. https://www.hcvguidelines.org/wp-content/uploads/2026/05/AASLD-IDSA_HCVGuidance_20260513_protected.pdf
  9. Performance Evaluation of the Xpert® HCV Test on Fingerstick Blood in a Prospective Observational Clinical Study at CLIA-Waived Sites in the United States | Clinical Infectious Diseases | Oxford Academic
  10. Viral Hepatitis Among People Experiencing Homelessness | Viral Hepatitis | CDC
  11. Recommendations of the Advisory Committee on Immunization Practices for Use of Hepatitis A Vaccine for Persons Experiencing Homelessness | MMWR
  12. A minimal monitoring approach for the treatment of hepatitis C virus infection (ACTG A5360 [MINMON]): a phase 4, open-label, single-arm trial - PubMed
  13. Accessible Hepatitis C Care for People Who Inject Drugs: A Randomized Clinical Trial - PMC
  14. Patient-centred models of hepatitis C treatment for people who inject drugs: a multicentre, pragmatic randomised trial
  15. Street-Based Hepatitis C Treatment and Patient Experiences Among Adults Experiencing Unsheltered Homelessness | Public Health | JAMA Network Open | JAMA Network
  16. Hepatitis C treatment outcomes among people who inject drugs experiencing unstable versus stable housing: Systematic review and meta-analysis - PubMed
  17. Facilitating access to direct-acting antivirals in a community-based point-of-diagnosis model for hepatitis C treatment: The role of the pharmacy team in the no one waits (NOW) study - ScienceDirect
  18. Updated Operational Guidance for Implementing CDC’s Recommendations on Testing for Hepatitis C Virus Infection | MMWR

Original Source(s)

Related Content