High progesterone may be tied to syringoma

Elevated levels occurred in 29% of women with the condition compared with 6% of controls in a cross-sectional study.

By
Andrea Surnit
August 31, 2026
3 min

MDSpire News

Overview

This study found that women with syringoma had significantly higher serum progesterone levels compared to controls, with elevated progesterone detected in 29% of patients with syringoma versus 6% of controls.

Background

Syringoma is a benign neoplasm that commonly affects the periorbital region, presenting as small flesh-colored papules. Understanding the hormonal associations with syringoma is important for potential therapeutic implications and further research into its etiology.

Data Highlights

Group	High Progesterone Levels
Syringoma Patients	10 of 35 (29%)
Controls	2 of 35 (6%)

Key Findings

29% of women with syringoma had high serum progesterone levels.
Only 6% of control women exhibited high progesterone levels.
Patients with syringoma had 6.6 times the odds of elevated progesterone compared to controls.
Localized syringoma was the most common form, affecting 51% of patients.
The inferior palpebral region was the most frequently affected area.

Clinical Implications

Further investigation into hormonal influences on sweat gland activity is warranted.

Conclusion

While the study indicates an association between high serum progesterone and syringoma, it does not establish causation. Further research is necessary to explore the underlying mechanisms.