Assessing the Impact of Outreach Strategies and Testing Procedures on Participation in Genetic Testing Among High-Risk Groups - Report - MDSpire

Assessing the Impact of Outreach Strategies and Testing Procedures on Participation in Genetic Testing Among High-Risk Groups

  • By

  • Lindsay Dickey

  • Emily Bryce

  • J. B. Rinaldi

  • Kate Emery

  • Kimberly Childers

  • Sandra Brown

  • Ora Gordon

  • Keri Vartanian

  • April 2, 2026

  • 0 min

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Clinical Report: Assessing Outreach Strategies for Genetic Testing Participation

Overview

This study evaluates the effectiveness of different outreach methods and clinic workflows on genetic testing participation among high-risk patients. Despite outreach efforts, genetic testing rates remained low, highlighting the need for improved access and integration into routine care.

Background

Genetic testing is crucial for precision medicine, particularly in identifying hereditary cancer risks. However, participation rates among eligible patients are alarmingly low, with significant disparities based on race, age, and insurance status. Understanding effective outreach strategies is essential to enhance testing uptake and reduce health disparities.

Data Highlights

Outreach MethodParticipation Rate
Mailed BrochureLow
EmailLow
SMS Text MessageLow
Same Building WorkflowHigher
Different Building WorkflowLower (IRR = 0.72)

Key Findings

  • Less than 3% of high-risk patients participated in genetic testing following outreach.
  • No significant difference in participation rates was observed among different outreach methods.
  • Patients offered testing in the same building had higher order rates compared to those required to go to a different building.
  • Disparities in order rates were more pronounced in the different building workflow.
  • Low-cost outreach methods, such as email, are feasible despite low engagement.
  • Point-of-care access is critical for improving participation and equity in genetic testing.

Clinical Implications

Healthcare systems should prioritize same-day genetic testing and enhance provider capacity to facilitate access. Integrating genetic testing into routine care, such as during mammography, may help bridge existing gaps in participation.

Conclusion

The study underscores the importance of effective outreach and workflow strategies in increasing genetic testing participation among high-risk patients. Continued efforts are needed to improve access and reduce disparities in genetic testing.

References

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  5. NCCN Guidelines® Insights - Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate, Version 2.2026 | NCCN Continuing Education
  6. A Randomized Trial of Two Remote Healthcare Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study - PMC
  7. Germline Genetic Testing After Cancer Diagnosis | Colorectal Cancer | JAMA | JAMA Network
  8. NCCN Guidelines® Insights - Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate, Version 2.2026 | NCCN Continuing Education
  9. A Randomized Trial of Two Remote Healthcare Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study - PMC
  10. Germline Genetic Testing After Cancer Diagnosis | Colorectal Cancer | JAMA | JAMA Network

Original Source(s)

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