Impact of rehabilitation trajectory on affective and cognitive impairment after intracerebral hemorrhage: a cohort study - Report - MDSpire

Impact of rehabilitation trajectory on affective and cognitive impairment after intracerebral hemorrhage: a cohort study

  • By

  • Qiuyi Jiang

  • Guangyao Shi

  • Hongli Zhang

  • Shouyue Wu

  • Chunyang Liu

  • Jian Zhang

  • Enzhou Lu

  • Chao Yuan

  • Yanchao Liang

  • Lu Wang

  • Guang Yang

  • June 10, 2026

  • 0 min

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Clinical Report: Effects of Rehabilitation Pathways on Cognitive and Emotional Dysfunction Following Intracerebral Hemorrhage

Overview

This cohort study examines the impact of rehabilitation trajectories on cognitive impairment, depression, and anxiety in patients with spontaneous intracerebral hemorrhage (ICH). Findings indicate that early rehabilitation is associated with better neuropsychiatric outcomes compared to late rehabilitation.

Background

Spontaneous intracerebral hemorrhage (ICH) is a significant cause of long-term disability and cognitive dysfunction. Understanding the effects of rehabilitation timing on cognitive and emotional recovery is crucial for improving patient outcomes. This study focuses on the relationship between rehabilitation pathways and neuropsychiatric impairments in ICH patients.

Data Highlights

GroupCognitive Impairment Odds RatioDepression Odds Ratio
Late Rehabilitation1.40 (95% CI 1.02–1.93, P = 0.036)1.96 (95% CI 1.47–2.62, P < 0.001)

Key Findings

  • 1,692 ICH patients were analyzed, with 1,563 included in the final analysis.
  • 75.5% of patients followed an early rehabilitation trajectory, while 24.5% followed a late rehabilitation trajectory.
  • Late rehabilitation was associated with higher odds of cognitive impairment and depression.
  • Factors such as male gender, smaller hematoma volume, and higher education were linked to increased risk of impairments in the late rehabilitation group.
  • Early rehabilitation is crucial for reducing long-term cognitive and affective impairments following ICH.

Clinical Implications

Healthcare providers should prioritize early rehabilitation for ICH patients to mitigate cognitive and emotional dysfunction. Tailoring rehabilitation strategies based on individual patient characteristics may enhance recovery outcomes.

Conclusion

The study highlights the importance of early rehabilitation in improving cognitive and emotional outcomes for ICH patients, suggesting a need for personalized rehabilitation strategies.

Related Resources & Content

  1. European Stroke Organisation (ESO) and European Association of Neurosurgical Societies (EANS), PMC, 2025 -- Guideline on stroke due to spontaneous intracerebral haemorrhage
  2. American Heart Association/American Stroke Association, ORA, 2023 -- Cognitive impairment after ischemic and hemorrhagic stroke: a scientific statement
  3. Frontiers in Neurology — Psychological resilience and functional recovery after acute ischemic stroke: a prospective cohort study
  4. Frontiers in Neurology — Modeling the evolution of disability acceptance after hypertensive intracerebral hemorrhage: a latent growth analysis
  5. Frontiers in Neurology — Identifying key predictors of post-stroke depression and cognitive impairment in acute stroke survivors
  6. Frontiers in Neurology — Network analysis of rehabilitation needs and influencing factors in aged patients recovering from first-time stroke
  7. European Stroke Organisation (ESO) and European Association of Neurosurgical Societies (EANS) guideline on stroke due to spontaneous intracerebral haemorrhage - PMC
  8. Cognitive impairment after ischemic and hemorrhagic stroke: a scientific statement from the American Heart Association/American Stroke Association - ORA - Oxford University Research Archive
  9. Frontiers | Effect of nonpharmacological interventions on poststroke depression: a network meta-analysis

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