Disseminated Mycobacterium kansasii infection with osseous involvement in anti-interferon-γ autoantibody-associated adult-onset immunodeficiency: a case report and literature review - Report - MDSpire
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Disseminated Mycobacterium kansasii infection with osseous involvement in anti-interferon-γ autoantibody-associated adult-onset immunodeficiency: a case report and literature review
Clinical Report: Disseminated Infection by Mycobacterium kansasii with Bone Involvement
Background
Anti–interferon-γ autoantibody-associated adult-onset immunodeficiency is a rare condition that predisposes individuals to opportunistic infections, particularly nontuberculous mycobacterial infections. Mycobacterium kansasii infections are uncommon and may present with symptoms and imaging findings that closely resemble malignancies, leading to potential diagnostic delays.
Data Highlights
No numerical data or trial data available in the source material.
Key Findings
A 53-year-old man with chronic hepatitis B presented with cough, chest pain, and back pain.
Imaging studies suggested malignancy, but repeated pathological examinations were nondiagnostic.
Next-generation sequencing confirmed the presence of Mycobacterium kansasii.
Elevated anti–IFN-γ autoantibodies were detected.
Complications included postoperative cholestatic jaundice and high-level HBV viremia.
Clinical Implications
In cases of suspected malignancy with nondiagnostic pathology, clinicians should consider testing for anti–IFN-γ autoantibodies and pathogen detection to avoid diagnostic delays. Awareness of the potential for Mycobacterium kansasii to mimic malignancy is crucial in managing patients with adult-onset immunodeficiency.
Conclusion
This case underscores the importance of integrating pathogen detection and immunologic testing in the diagnostic process for disseminated infections that may mimic malignancies.
