Couple-level dyslipidemia and embryological and cumulative pregnancy outcomes in IVF/ICSI cycles: a single-center retrospective cohort study - Report - MDSpire

Couple-level dyslipidemia and embryological and cumulative pregnancy outcomes in IVF/ICSI cycles: a single-center retrospective cohort study

  • By

  • Ruobing Lei

  • Shuyi Chen

  • Weihong Li

  • June 18, 2026

  • 0 min

Share

Clinical Report: Impact of Couple-Level Dyslipidemia on IVF/ICSI Outcomes

Overview

This study investigates the impact of dyslipidemia in both partners on embryological and cumulative pregnancy outcomes in couples undergoing IVF/ICSI.

Background

Dyslipidemia is a metabolic condition that can affect reproductive health and outcomes in assisted reproductive technology (ART) such as IVF/ICSI. This study aims to clarify the associations between dyslipidemia in both partners and reproductive outcomes.

Data Highlights

OutcomeAssociation
Cumulative miscarriageFemale dyslipidemia: aOR = 4.455
Cumulative live birthFemale dyslipidemia: aOR = 0.335
Cumulative live birthMale dyslipidemia: aOR = 0.309
Cumulative miscarriageBilateral dyslipidemia: aOR = 10.579
Cumulative live birthBilateral dyslipidemia: aOR = 0.116

Key Findings

  • Women with dyslipidemia had longer stimulation duration and higher gonadotropin doses.
  • Male dyslipidemia was linked to fewer transferable embryos and lower fertilization rates.
  • Bilateral dyslipidemia correlated with less favorable embryological outcomes.
  • Female dyslipidemia increased odds of cumulative miscarriage and decreased odds of live birth.
  • Male dyslipidemia was associated with lower odds of cumulative live birth.

Clinical Implications

The findings suggest that dyslipidemia in both partners may be relevant when evaluating couples for IVF/ICSI.

Conclusion

Dyslipidemia in either or both partners negatively impacts embryological and cumulative pregnancy outcomes in IVF/ICSI cycles.

Related Resources & Content

  1. Frontiers in Endocrinology, 2026 -- Couple-Level Dyslipidemia and Embryological and Cumulative Pregnancy Outcomes in IVF/ICSI Cycles: A Single-Center Retrospective Cohort Study
  2. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Impact of Dyslipidemia on Immune Function and Endometrial Receptivity in Women Experiencing Repeated Implantation Failure
  3. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Effects of Negative Pregnancy Experiences in the First IVF Cycle on Future Pregnancy Results
  4. Frontiers in Endocrinology — Impact of trigger-day serum luteinizing hormone levels on embryo quality and pregnancy outcomes in overweight and obese women undergoing GnRH antagonist protocols: a retrospective cohort study
  5. Frontiers in Endocrinology — Effect of basal LH levels on pregnancy outcome after IVF/ICSI fresh embryo transfer in patients of different ages: a retrospective study
  6. Dyslipidemia Management in Women of Reproductive Potential: An Expert Clinical Consensus from the National Lipid Association
  7. ESHRE Ovarian Stimulation Guideline (2025 Update)
  8. Frontiers | Couple-Level Dyslipidemia and Embryological and Cumulative Pregnancy Outcomes in IVF/ICSI Cycles: A Single-Center Retrospective Cohort Study
  9. https://academic.oup.com/jcem/article/110/11/3230/8026605
  10. P-689 Impact of dyslipidaemia on the probability of pregnancy in women undergoing IVF: a systematic review and meta-analysis | Human Reproduction | Oxford Academic

Original Source(s)

Couple-level dyslipidemia and embryological and cumulative pregnancy outcomes in IVF/ICSI cycles: a single-center retrospective cohort study

  • by Ruobing Lei, Shuyi Chen, Weihong Li

  • June 18, 2026

Related Content

Remote Monitoring Lowers Postpartum BP

Meta-analysis finds telemonitoring improves blood pressure after hypertensive pregnancy, while medications show no clear benefit

NPs Top US Jobs List Again

The nurse practitioner profession claims the No. 1 spot across three categories in the U.S. News & World Report 2026 Best Jobs rankings for the third consecutive year.

Why Maternal Co-morbidities Matter for Newborn Care

Analysis shows higher rates of severe morbidity and mortality with increasing maternal conditions

  • February 10, 2026

  • 3 min