The association between the red blood cell distribution width-to-albumin ratio and in-hospital mortality in cardiac arrest patients: an analysis of the eICU database - Report - MDSpire

The association between the red blood cell distribution width-to-albumin ratio and in-hospital mortality in cardiac arrest patients: an analysis of the eICU database

  • By

  • Yuyuan Wang

  • Xin Yuan

  • Dongxia Wang

  • Chaoxi Liu

  • Ruihua Wang

  • July 16, 2026

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Clinical Report: RAR and In-Hospital Mortality in Cardiac Arrest Patients

Overview

This study investigates the relationship between the red blood cell distribution width-to-albumin ratio (RAR) and in-hospital mortality in patients experiencing cardiac arrest.

Background

Cardiac arrest leads to significant systemic injury and is a major cause of mortality in intensive care settings. Identifying reliable prognostic markers is crucial for improving patient outcomes. The RAR, a composite index of red blood cell distribution width and serum albumin, has been studied in various cardiovascular conditions.

Data Highlights

MeasureValue
Mean Age63.1 years
Male Percentage58.5%
Adjusted Odds Ratio (for RAR)1.16 (95% CI: 1.10–1.22)
P for trend (highest vs lowest RAR tertile)<0.001

Key Findings

  • A nonlinear relationship exists between RAR and in-hospital mortality.
  • The association is stronger below the RAR threshold of 5.354.
  • Each one-unit increase in RAR correlates with a higher mortality risk.
  • Patients in the highest RAR tertile have significantly higher mortality risk compared to those in the lowest tertile.

Clinical Implications

Further validation of RAR's predictive performance is necessary before clinical application.

Conclusion

Elevated RAR is associated with increased in-hospital mortality in cardiac arrest patients.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- The Prognostic Value of Red Cell Distribution Width-to-Albumin Ratio for 28-Day Mortality in Sepsis Patients: A Multicenter Analysis Based on the eICU Collaborative Research Database
  2. Frontiers in Medicine, 2026 -- LDAR Outperforms Other Albumin-Derived Indices in Predicting 28-Day ICU Mortality in Critically Ill Myocardial Infarction Patients: A Two-Cohort Study
  3. Frontiers in Medicine, 2026 -- Hematologic and metabolic indices for predicting 28-day mortality in sepsis patients: a retrospective intensive care cohort study
  4. Part 11: Post-Cardiac Arrest Care | American Heart Association CPR & First Aid
  5. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2025 Post-Resuscitation Care
  6. Frontiers in Medicine — Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database
  7. Part 11: Post-Cardiac Arrest Care | American Heart Association CPR & First Aid
  8. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2025 Post-Resuscitation Care
  9. A systematic review and dose-response meta-analysis of red blood cell distribution width to albumin ratio as mortality predictor in cardiovascular disease | Scientific Reports

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