The modifying effect of diabetes on the association between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular risk: a systematic review and meta-analysis - Report - MDSpire
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The modifying effect of diabetes on the association between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular risk: a systematic review and meta-analysis
Clinical Report: The Impact of Diabetes on TG/HDL Cholesterol Ratio and CVD Risk
Overview
This systematic review and meta-analysis evaluated the association between the triglyceride to HDL cholesterol (TG/HDL-C) ratio and cardiovascular risk, focusing on the modifying effect of diabetes. The findings indicate that the TG/HDL-C ratio is associated with cardiovascular events and all-cause mortality in both diabetic and non-diabetic populations, with associations for stroke and coronary heart disease being stronger in individuals with diabetes.
Background
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality, particularly among individuals with type 2 diabetes mellitus (T2DM). The TG/HDL-C ratio serves as a simple, cost-effective indicator of insulin resistance and lipid metabolism disorders, which are critical in assessing cardiovascular risk.
Data Highlights
Outcome
Hazard Ratio (HR)
P-value
Cardiovascular events (DM)
1.53
0.76
Cardiovascular events (non-DM)
1.47
All-cause mortality (DM)
1.25
0.89
All-cause mortality (non-DM)
1.23
Stroke (DM)
1.79
0.04
Stroke (non-DM)
1.23
Coronary heart disease (DM)
1.62
0.003
Coronary heart disease (non-DM)
0.88
Key Findings
The TG/HDL-C ratio is associated with cardiovascular events and all-cause mortality in both diabetic and non-diabetic populations.
The hazard ratio for cardiovascular events was 1.53 in individuals with diabetes compared to 1.47 in those without diabetes.
For all-cause mortality, the hazard ratios were 1.25 for diabetic individuals and 1.23 for non-diabetic individuals.
Stroke risk was significantly higher in diabetic individuals (HR: 1.79) compared to non-diabetic individuals (HR: 1.23).
Coronary heart disease risk was also higher in the diabetic group (HR: 1.62) compared to the non-diabetic group (HR: 0.88).
Clinical Implications
Healthcare professionals should consider the TG/HDL-C ratio as a relevant marker for cardiovascular risk assessment in both diabetic and non-diabetic patients. The stronger associations observed in diabetic individuals for stroke and coronary heart disease highlight the need for targeted cardiovascular risk management in this population.
Conclusion
The findings indicate that the TG/HDL-C ratio is a useful indicator of cardiovascular risk across different diabetes statuses, with diabetes enhancing the risk for specific cardiovascular events such as stroke and coronary heart disease.
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