Intervention–analog association between traditional Chinese medicine syndrome load and lipid/C-reactive protein biomarkers: a single-center retrospective cohort study using target trial emulation - Report - MDSpire
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Intervention–analog association between traditional Chinese medicine syndrome load and lipid/C-reactive protein biomarkers: a single-center retrospective cohort study using target trial emulation
Association of Traditional Chinese Medicine Syndrome Load with Lipid and C-Reactive Protein Biomarkers
Overview
This study investigates the relationship between Traditional Chinese Medicine (TCM) syndrome load and biochemical markers, specifically lipid levels and C-reactive protein (CRP). A higher syndrome load was associated with increased levels of triglycerides, low-density lipoprotein cholesterol, and CRP.
Background
Traditional Chinese Medicine syndrome differentiation is crucial for personalized diagnosis and treatment. This study addresses the gap in evidence linking TCM syndromes with measurable health outcomes.
Data Highlights
Biomarker
Association with 1-SD Higher Syndrome Load
95% Confidence Interval
Triglycerides (TG)
+0.18
(0.12–0.24)
Low-Density Lipoprotein Cholesterol (LDL-C)
+0.11
(0.05–0.18)
C-Reactive Protein (CRP)
+0.16
(0.09–0.23)
Key Findings
CFA/IRT models showed good fit (CFI = 0.96, RMSEA = 0.042).
A 1-SD higher syndrome load correlated with increased TG, LDL-C, and CRP z-scores.
Associations were stronger in participants aged ≥65 years, those with diabetes, or BMI ≥ 28.
Baseline laboratory sensitivity analyses yielded consistent estimates for TG, LDL-C, and CRP.
No material positivity violations were observed in the study.
Clinical Implications
The findings indicate that TCM syndrome load is associated with lipid and CRP biomarkers.
Conclusion
The study establishes a significant association between TCM syndrome load and lipid/CRP biomarkers.
