Targeting Mitochondrial Dynamics with Herbal Extracts in Atherosclerosis
Overview
This study investigates the effects of herbal extracts on mitochondrial dynamics in endothelial cells exposed to oxidized LDL.
Background
Mitochondrial dysfunction is a significant factor in the early stages of atherosclerosis, contributing to endothelial injury and cardiovascular diseases. This study explores the potential of herbal extracts to modulate mitochondrial dynamics and improve endothelial cell function.
Data Highlights
Extract
Effect on Mitochondrial Dynamics
Gene Expression Changes
Rosmarinus officinalis
Preserved Δψm
Increased FUNDC1, OPTN
Cynara cardunculus
Enhanced mitophagy
Upregulated PINK1, PARKIN
Myrtus communis
Preserved mitochondrial architecture
Increased FUNDC1, OPTN
Key Findings
All extracts preserved mitochondrial membrane potential in healthy HUVECs.
In the ox-LDL model, extracts downregulated pro-fission genes (DRP1, FIS1, MFF).
Extracts restored expression of fusion proteins (MFN2, OPA1).
Rosmarinus officinalis and Myrtus communis increased receptor-mediated clearance pathways (FUNDC1, OPTN).
All extracts enhanced antioxidant enzyme expression (CAT) and suppressed pro-inflammatory MAPK8 (JNK).
Clinical Implications
The findings suggest that herbal extracts may serve as adjunctive therapies to support endothelial health and mitigate atherosclerosis progression. Further research is needed to explore the clinical applicability of these extracts in cardiovascular disease prevention.
Conclusion
Herbal extracts demonstrate potential in protecting endothelial cells from oxidized LDL-induced damage by modulating mitochondrial dynamics.
