Correlation Between Ultrasound-Determined Muscle Metrics and Liver Stiffness
Overview
This study investigates the diagnostic value of high-frequency ultrasound and 2D-SWE in assessing low muscle mass in cirrhotic patients.
Background
Sarcopenia, characterized by progressive skeletal muscle loss, is prevalent in cirrhosis patients and is associated with poor outcomes. Traditional diagnostic methods for sarcopenia have limitations, prompting the exploration of non-invasive ultrasound techniques.
Data Highlights
Parameter
CRS Group
NC Group
Cirrhosis Group
Muscle Thickness (MT)
Lower
Higher
Higher
Shear Wave Velocity (SWV)
Lower
Higher
Higher
Liver Elastic Modulus (LEM)
Higher
Lower
Lower
Key Findings
The CRS group exhibited lower muscle thickness (MT) and shear wave velocity (SWV) compared to NC and cirrhosis groups.
Higher liver elastic modulus (LEM) was observed in the CRS group.
ASMI positively correlated with BMI, serum albumin, MT, and muscle SWV.
ASMI negatively correlated with age, total bilirubin, LEM, and INR.
Combined assessment of muscle parameters and LEM showed an AUC of 0.919 for diagnosing CRS.
Clinical Implications
Ultrasound measurements of muscle metrics and liver stiffness can serve as effective diagnostic tools for identifying sarcopenia in cirrhotic patients.
Conclusion
The study demonstrates that ultrasound-derived muscle metrics combined with liver stiffness measurements provide a robust diagnostic approach for cirrhosis-associated sarcopenia.
