Machine and deep learning based on magnetic resonance imaging to segment glioblastoma and predict the spread of recurrence: a multicenter retrospective protocol - Report - MDSpire

Machine and deep learning based on magnetic resonance imaging to segment glioblastoma and predict the spread of recurrence: a multicenter retrospective protocol

  • By

  • Luana Conte

  • Erica Lo Turco

  • Rosaria V. Abbritti

  • Caterina Accettura

  • Giuseppe Raso

  • Edvige Iaboni

  • Ugo De Giorgi

  • Giorgio De Nunzio

  • Donato Cascio

  • Maria Caffo

  • July 10, 2026

  • 0 min

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Clinical Report: Utilizing Machine Learning and Deep Learning Techniques on MRI for Glioblastoma Segmentation and Recurrence Prediction

Overview

This study protocol outlines the use of machine learning and deep learning techniques on MRI data to predict glioblastoma recurrence and develop a semi-automatic segmentation tool.

Background

Glioblastoma (GB) is a highly aggressive brain tumor characterized by poor prognosis and high recurrence rates. Accurate prediction of recurrence patterns is essential for optimizing surgical interventions and subsequent treatments. This study seeks to leverage advanced imaging and machine learning techniques.

Data Highlights

No numerical data available in the provided source material.

Key Findings

  • The study proposes using machine learning and deep learning for MRI data analysis in GB patients.
  • Predictive models will be developed to forecast the extent of recurrence spread based on clinical and imaging data.
  • A semi-automatic segmentation tool for tumor delineation will be created to standardize volume measurement in neuroimaging.
  • Model performance will be evaluated using various metrics, including AUC and Dice score for segmentation.

Clinical Implications

The integration of machine learning and deep learning techniques in GB management may enhance the precision of recurrence predictions, thereby informing surgical strategies. This could lead to improved patient outcomes and more efficient use of healthcare resources.

Conclusion

The proposed study aims to investigate glioblastoma recurrence through innovative imaging techniques.

Related Resources & Content

  1. Utilizing Deep Learning for Glioblastoma MRI Segmentation to Reveal Volumetric Characteristics Linked to Patient Survival, Journal of Neuro-Oncology, 2020
  2. Utilizing Multimodal Neuroimaging and Machine Learning to Forecast Survival Outcomes in Glioblastoma, Journal of Neuro-Oncology, 2023
  3. Predicting Survival in Glioblastoma Using Integrated MRI and Clinical Data via Transfer Learning Techniques, Journal of Neuro-Oncology, 2025
  4. Whole-Brain MR-Spectroscopy Metabolic Profiles Reveal Early Tumor Advancement in High-Grade Gliomas Through Machine Learning Techniques, Journal of Neuro-Oncology, 2024
  5. What’s new in neuropathology 2024: CNS WHO 5th edition updates, PMC
  6. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma, New England Journal of Medicine
  7. What’s new in neuropathology 2024: CNS WHO 5th edition updates - PMC
  8. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma | New England Journal of Medicine
  9. https://academic.oup.com/neuro-oncology/article/27/11/2751/8237727?searchresult=1

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