Clinical Report: Vasoactive-Age Adjusted Sepsis-Induced Coagulopathy Score

Overview

The Vasoactive-Age adjusted Sepsis-Induced Coagulopathy (VAS) score predicts 28-day new-onset multiple organ dysfunction syndrome (MODS) in sepsis patients, with an area under the curve (AUC) of 0.777, outperforming the traditional SIC score (AUC 0.708).

Background

Sepsis is a critical condition characterized by life-threatening organ dysfunction due to an unregulated response to infection. Accurate early identification of patients at high risk for multiple organ dysfunction syndrome (MODS) is essential. Current risk stratification tools often overlook key factors such as age and coagulation status.

Data Highlights

Key Findings

• The VAS score has an AUC of 0.777, significantly higher than the SIC score (0.708).
• New-onset MODS occurred in 29.9% of the studied sepsis patients.
• VAS ≥ 4 is independently predictive of MODS with a hazard ratio of 3.42.
• Dynamic increases in VAS over 48 hours are associated with a 4.78-fold higher risk of MODS.
• Combining VAS with biomarkers like lactate and procalcitonin increases predictive accuracy (AUC 0.853).

Clinical Implications

The VAS score provides a tool for clinicians to identify sepsis patients at high risk for MODS early in their treatment.

Conclusion

The VAS score is a valuable addition to existing sepsis risk stratification tools, offering improved predictive capabilities for MODS.

Related Resources & Content

1. Frontiers in Anesthesiology, 2026 -- Comparison of SOFA score alone versus SOFA score with interleukin-6 for outcome prediction in ICU patients with sepsis
2. Infection, 2022 -- A Two-Year Retrospective Study on the Prognostic Significance of MqSOFA in Comparison to Lactate, NEWS, and qSOFA in Sepsis Patients
3. Frontiers in Medicine, 2026 -- Comparative predictive value of nine inflammation-derived haematological indices for 28-day mortality in patients with sepsis
4. Intensive Care Medicine, 2015 -- Assessment of Arterial Lactate and Venous-Arterial CO2 to Arterial-Venous O2 Content Ratio as Indicators of Resuscitation in Septic Shock Patients
5. Surviving Sepsis Campaign, 2026 -- international guidelines for management of sepsis and septic shock
6. Sepsis-induced coagulopathy (SIC) in the management of sepsis
7. Thrombosis, bleeding, and mortality in patients with sepsis-induced coagulopathy
8. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026 | Intensive Care Medicine | Springer Nature Link
9. A comparison of disseminated intravascular coagulation scoring systems and their performance to predict mortality in sepsis patients: A systematic review and meta-analysis - PMC
10. Frontiers | Prognostic evaluation of the norepinephrine equivalent score and the vasoactive-inotropic score in patients with sepsis and septic shock: a retrospective cohort study
11. Sepsis and Septic Shock | New England Journal of Medicine
12. Surviving Sepsis Campaign Adult Guidelines | SCCM