Comparison of early clinical and optical quality-related outcomes after SMILE using VisuMax 800 versus VisuMax 500 for myopia and low-to-moderate astigmatism in a Chinese population: a single-center retrospective study - Report - MDSpire

Comparison of early clinical and optical quality-related outcomes after SMILE using VisuMax 800 versus VisuMax 500 for myopia and low-to-moderate astigmatism in a Chinese population: a single-center retrospective study

  • By

  • Xuanyu Yang

  • Jiabin Leng

  • Yuchen Mei

  • Fei Peng

  • Yifan Xie

  • Linlin Liu

  • Linhua Wan

  • Liping Liu

  • Wentian Zhou

  • Hui Zhang

  • April 30, 2026

  • 0 min

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Clinical Report: Evaluation of SMILE with VisuMax 800 vs 500 for Myopia

Overview

This study compares early clinical outcomes and optical quality metrics of SMILE performed with VisuMax 800 and VisuMax 500 in a Chinese cohort. Both platforms demonstrated favorable safety and efficacy, but the VisuMax 800 showed advantages in lenticule creation time and optical zone decentration.

Background

Detail the specific limitations of VisuMax 500 that the VisuMax 800 aims to overcome.

Data Highlights

ParameterVisuMax 500VisuMax 800P-value
Lenticule Creation Time (s)27.43 ± 2.269.47 ± 0.88< 0.01
Absolute Y-axis DecentrationHigherLower< 0.01
Total Optical Zone DecentrationHigherLower< 0.01
Postoperative Vertical ComaHigherLower0.004
Residual Cylindrical ErrorHigherLower0.048

Key Findings

  • No significant differences in uncorrected or corrected distance visual acuity between groups (p > 0.05).
  • SMILE Pro (VisuMax 800) had a significantly shorter lenticule creation time compared to SMILE (VisuMax 500).
  • Lower absolute Y-axis decentration and total optical zone decentration were observed in the SMILE Pro group.
  • Postoperative vertical coma was significantly lower in the SMILE Pro group (p = 0.004).
  • Residual cylindrical error was lower in the SMILE Pro group (p = 0.048).

Clinical Implications

The findings suggest that the VisuMax 800 platform may enhance surgical efficiency and optical outcomes in SMILE procedures. Clinicians should consider these advantages when selecting a laser platform for myopia and astigmatism correction.

Conclusion

Strengthen the call for further studies by specifying the types of studies needed.

References

  1. Academy of Asia-Pacific Professors of Ophthalmology, ScienceDirect, 2025 -- Controversies, consensuses and guidelines on Small Incision Lenticule Extraction (SMILE)
  2. Frontiers, 2026 -- Comparison of Early Clinical and Optical Quality-Related Outcomes after SMILE using VisuMax 800 versus VisuMax 500
  3. Contact Lens Spectrum, September 2023 -- MASTERING MYOPIA
  4. Contact Lens Spectrum, January 2023 -- MASTERING MYOPIA
  5. Corneal Physician, April 2021 -- The Future of Corneal Refractive Surgery
  6. Contact Lens Spectrum — LESSONS LEARNED FROM THE THREE-YEAR RETROSPECTIVE ASSESSMENT FOR MYOPIA MANAGEMENT
  7. Controversies, consensuses and guidelines on Small Incision Lenticule Extraction (SMILE) by the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO) and the Asia-Pacific Myopia Society (APMS) - ScienceDirect
  8. Frontiers | Comparison of Early Clinical and Optical Quality-Related Outcomes after SMILE using VisuMax 800 versus VisuMax 500 for Myopia and Low-to-Moderate Astigmatism in a Chinese Population: A Single-Center Retrospective Study
  9. Factors Influencing Astigmatic Correction Using Small-Incision Lenticule Extraction: A Systematic Review and Meta-Analysis - PMC

Original Source(s)

Comparison of early clinical and optical quality-related outcomes after SMILE using VisuMax 800 versus VisuMax 500 for myopia and low-to-moderate astigmatism in a Chinese population: a single-center retrospective study

  • by Xuanyu Yang, Jiabin Leng, Yuchen Mei, Fei Peng, Yifan Xie, Linlin Liu, Linhua Wan, Liping Liu, Wentian Zhou, Hui Zhang

  • April 30, 2026

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