Clinical Report: Assessment of Tegileridine's Efficacy and Safety in Pain Management

Overview

This meta-analysis evaluates the efficacy and safety of tegileridine in postoperative pain management, demonstrating significant analgesic efficacy compared to placebo and a favorable safety profile compared to morphine.

Background

Postoperative acute pain management is a critical issue, with many patients experiencing inadequate analgesia, which can lead to chronic pain and increased healthcare costs. Opioids are commonly used but are associated with significant adverse effects.

Data Highlights

Key Findings

• Tegileridine significantly reduced rSPID24 and rSPID12 compared to placebo.
• No significant difference in rSPID12 efficacy between tegileridine and morphine.
• Tegileridine exhibited significantly weaker efficacy than morphine at rSPID24.
• The incidence of nausea and vomiting with tegileridine was similar to placebo and lower than morphine.
• No significant difference in respiratory depression was observed between tegileridine and morphine.

Clinical Implications

Tegileridine may serve as a viable alternative for postoperative acute pain management, particularly due to its favorable safety profile regarding nausea and vomiting compared to morphine. Clinicians should consider its use in multimodal analgesic strategies.

Conclusion

The findings from this meta-analysis support the efficacy of tegileridine over placebo.

Related Resources & Content

1. Jiangsu Hengrui Pharmaceuticals, Meta-Analysis, 2026 -- Assessment of Tegileridine's Efficacy and Safety Across Various Doses in Postoperative Pain Management
2. ERAS Society, Anesthesia Guidelines, 2026 -- Effective Multimodal, Opioid-Sparing Analgesia
3. NMPA, 2024 -- Tegileridine Fumarate Injection Approved for Marketing
4. Strategies for Pharmacologic Management of Postoperative Pain Following Total Knee Arthroplasty: A Comprehensive Review of Molecular Mechanisms and Clinical Effectiveness
5. A comprehensive review and meta-analysis examining the impact of intravenous dexamethasone on postoperative results in patients receiving total knee arthroplasty
6. Frontiers in Medicine — Efficacy and safety of oliceridine in daytime hysteroscopic polypectomy: a randomized, double-blind, single-center controlled trial
7. Systematic Review and Meta-Analysis of Analgesic Approaches for Managing Postoperative Pain Following Pancreatic Resection
8. Tegileridine for moderate-to-severe acute pain following abdominal surgery
9. Anaesthesia - ERAS® Society
10. Tegileridine Fumarate Injection Approved for Marketing by China NMPA