Clinical Report: Enhancing IVF/ICSI Success Rates in Older Women Through Embryo Accumulation
Overview
This study investigates the impact of an embryo accumulation strategy on reproductive outcomes in advanced-age women undergoing IVF/ICSI.
Background
As women age, particularly after 35, their reproductive potential declines, leading to lower natural conception rates and challenges in achieving successful pregnancies through assisted reproductive technologies (ART). Advanced-age women often face diminished oocyte quantity and quality, resulting in fewer transferable embryos during IVF cycles. Optimizing reproductive outcomes for this demographic remains a critical clinical challenge.
Data Highlights
Outcome
Embryo Accumulation Group
Control Group
P-value
Biochemical Pregnancy Rate
Higher
Lower
< 0.001
Cumulative Live Birth Rate (CLBR)
Higher (OR = 2.75)
Lower
< 0.001
Cumulative Clinical Pregnancy Rate (CCPR)
Higher (OR = 2.71)
Lower
< 0.001
Miscarriage Rate
No significant difference
No significant difference
0.583
Key Findings
Embryo accumulation significantly increased CLBR and CCPR in advanced-age women.
Higher CLBR and CCPR were observed when the cumulative embryo number was ≤ 2.
No significant difference in miscarriage rates between the embryo accumulation and control groups.
Propensity score matching was utilized to eliminate baseline confounding bias.
Binary logistic regression confirmed the correlation between embryo accumulation and improved reproductive outcomes.
Clinical Implications
Clinical decisions should consider individual patient assessments beyond embryo quantity.
Conclusion
Embryo accumulation through consecutive stimulation cycles can improve reproductive outcomes in advanced-age women receiving IVF/ICSI.
