Association of four non-insulin-based insulin resistance surrogate markers with colorectal cancer risk: a large-scale prospective cohort study using the UK Biobank - Report - MDSpire

Association of four non-insulin-based insulin resistance surrogate markers with colorectal cancer risk: a large-scale prospective cohort study using the UK Biobank

  • By

  • Ye Ding

  • Jie Wang

  • Nan Wang

  • Jinyu Zhu

  • Xiaoxiao Wang

  • Peibei Duan

  • July 10, 2026

  • 0 min

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Clinical Report: Evaluation of Non-Insulin Surrogate Markers for Insulin Resistance

Overview

This study evaluates four non-insulin surrogate markers for insulin resistance (IR) and their correlation with colorectal cancer (CRC) risk in a large cohort.

Background

Colorectal cancer (CRC) is a significant global health issue, with rising incidence linked to metabolic dysfunction and insulin resistance (IR).

Data Highlights

Surrogate MarkerHazard Ratio (HR)95% Confidence Interval (CI)
TyG index1.16(1.07-1.26)
TyG-BMI1.20(1.11-1.31)
TG/HDL-C ratio1.09(1.01-1.19)
METS-IR1.21(1.11-1.32)

Key Findings

  • All four non-insulin-based IR surrogates were independently associated with CRC risk (P < 0.001).
  • METS-IR and TyG-BMI showed the most significant improvements in discrimination (C-index increments = 0.0015; P < 0.001).
  • Significant non-linear relationships were observed for the TyG index and METS-IR.
  • Subgroup analyses indicated significant interactions with age, sex, and smoking status (P-interaction ≤ 0.05).
  • Robustness of findings was confirmed through multiple sensitivity analyses.

Clinical Implications

The study presents findings on non-insulin-based IR surrogates and their association with CRC risk.

Conclusion

The findings indicate the association of non-insulin-based IR surrogates with CRC risk.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Author(s)/Org, Source, Year -- Title
  3. Author(s)/Org, Source, Year -- Title
  4. Validation of the LiFeCRC Colorectal Cancer Risk Score Through Food Frequency Assessments in the HUNT Study
  5. Colorectal cancer screening: An update to the American Cancer Society guideline, 2026 - PubMed
  6. Association between triglyceride-glucose index and risk of colorectal carcinogenesis: a meta-analysis of observational studies
  7. Machine learning-predicted insulin resistance is a risk factor for 12 types of cancer - UK Biobank
  8. Colorectal cancer screening: An update to the American Cancer Society guideline, 2026 - PubMed
  9. Association between triglyceride-glucose index and risk of colorectal carcinogenesis: a meta-analysis of observational studies
  10. Machine learning-predicted insulin resistance is a risk factor for 12 types of cancer - UK Biobank

Original Source(s)

Association of four non-insulin-based insulin resistance surrogate markers with colorectal cancer risk: a large-scale prospective cohort study using the UK Biobank

  • by Ye Ding, Jie Wang, Nan Wang, Jinyu Zhu, Xiaoxiao Wang, Peibei Duan

  • July 10, 2026

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