Association between the C-reactive protein-triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome - Report - MDSpire

Association between the C-reactive protein-triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome

  • By

  • Cailin Feng

  • Jiasuer Alifu

  • Wen Zhang

  • Lu Liu

  • Guoqing Yin

  • Abdul-Quddus Mohammed

  • Fuad A. Abdu

  • Wenliang Che

  • July 1, 2026

  • 0 min

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Clinical Report: Link Between C-Reactive Protein-Triglyceride-Glucose Index and Coronary Microvascular Dysfunction Prognosis in Chronic Coronary Syndrome Patients

Overview

The C-reactive protein-triglyceride-glucose index (CTI) is identified as a predictor of coronary microvascular dysfunction (CMD) and major adverse cardiovascular events (MACE) in patients with chronic coronary syndrome (CCS). Higher CTI levels correlate with increased risk of MACE, particularly in CMD patients.

Background

Coronary microvascular dysfunction (CMD) is a significant contributor to adverse outcomes in chronic coronary syndromes (CCS), affecting patient morbidity and mortality. Early identification and risk stratification for CMD are crucial for improving patient management. The CTI integrates inflammation and insulin resistance metrics.

Data Highlights

MetricResult
CTI and CMD association (Q4 vs. Q1)OR: 2.28, 95% CI: 1.16–4.49, p = 0.017
CTI and MACE risk (Q4)HR: 2.62, 95% CI: 1.25–5.51, p = 0.011
CTI and MACE risk in CMD patientsHR: 2.84, 95% CI: 1.06–7.62, p = 0.039
CTI predictive accuracy vs. TyGDeLong test p = 0.020

Key Findings

  • CTI is independently associated with CMD in CCS patients.
  • Higher CTI levels predict increased risk of MACE over a median follow-up of 35 months.
  • CTI outperforms TyG and CRP in predicting CMD-related MACE.
  • CMD is linked to worse prognosis across various cardiovascular conditions.
  • Insulin resistance and inflammation are key factors in CMD development.

Clinical Implications

The CTI can serve as a biomarker for risk stratification in patients with chronic coronary syndrome.

Conclusion

CTI is a predictor of CMD and MACE in CCS patients.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Association between the C-reactive protein-triglyceride-glucose index and major adverse cardiovascular events in patients undergoing percutaneous coronary intervention
  2. Frontiers in Cardiovascular Medicine, 2026 -- Prognostic significance of stress hyperglycemia ratio in coronary microvascular dysfunction among chronic coronary syndrome patients
  3. Frontiers in Cardiovascular Medicine, 2026 -- Development and validation of the C-reactive protein–triglyceride-glucose index for predicting short- and long-term mortality in critically ill patients with coronary artery disease: a multicenter cohort study
  4. Frontiers in Endocrinology, 2026 -- Association of the hs-CRP-TyG Index with Coronary Artery Disease Risk and Angiographic Severity: A Retrospective Comparative Study with the TyG Index
  5. State of the Art: Evaluation and Medical Management of Nonobstructive Coronary Artery Disease in Patients With Chest Pain: A Scientific Statement From the American Heart Association - PubMed
  6. Endotyping-informed therapy for patients with chest pain and no obstructive coronary artery disease: a randomized trial - PubMed
  7. State of the Art: Evaluation and Medical Management of Nonobstructive Coronary Artery Disease in Patients With Chest Pain: A Scientific Statement From the American Heart Association - PubMed
  8. https://academic.oup.com/eurjpc/article/33/Supplement_2/zwag249.280/8706169

Original Source(s)

Association between the C-reactive protein-triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome

  • by Cailin Feng, Jiasuer Alifu, Wen Zhang, Lu Liu, Guoqing Yin, Abdul-Quddus Mohammed, Fuad A. Abdu, Wenliang Che

  • July 1, 2026

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