Hospitalization Outcomes for Atrial Tachyarrhythmias with Thoracic Radiation
Overview
This study investigates the hospitalization outcomes for patients with atrial fibrillation or flutter who have a history of thoracic radiation therapy (TRT). It finds that TRT is associated with higher in-hospital mortality and longer length of stay.
Background
Thoracic radiation therapy is a common treatment for various cancers, but its long-term cardiovascular effects, particularly regarding arrhythmias, are not fully understood. Atrial fibrillation and flutter are prevalent among patients who have undergone TRT, potentially leading to increased hospitalization rates and complications.
Data Highlights
Outcome
TRT Group
Non-TRT Group
In-hospital mortality (aOR)
1.97 (95% CI 1.17–3.32; p=0.010)
Reference
Length of stay (days)
+0.30 (95% CI 0.05–0.55; p=0.019)
Reference
Palliative consultation (aOR)
2.60 (p<0.001)
Reference
DNR status (aOR)
1.97 (p<0.001)
Reference
Acute kidney injury (aOR)
0.66 (p<0.001)
Reference
Key Findings
TRT is associated with higher odds of in-hospital mortality (aOR 1.97).
Patients with TRT had a longer length of stay by an average of 0.30 days.
Higher odds of palliative consultation were noted in the TRT group (aOR 2.60).
Patients with TRT had increased odds of DNR status (aOR 1.97).
Lower odds of acute kidney injury were observed in the TRT group (aOR 0.66).
Clinical Implications
Healthcare providers should be aware of the increased mortality and complexity in managing patients with atrial tachyarrhythmias who have a history of thoracic radiation therapy. This may necessitate tailored care strategies and multidisciplinary approaches to address their unique needs.
Conclusion
The findings indicate that prior thoracic radiation therapy significantly impacts hospitalization outcomes for patients with atrial tachyarrhythmias.
