Trends and disparities in deaths involving atherosclerotic cardiovascular disease and stroke-related conditions among U.S. adults, 1999–2025 - Report - MDSpire
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Trends and disparities in deaths involving atherosclerotic cardiovascular disease and stroke-related conditions among U.S. adults, 1999–2025
Clinical Report: Mortality Trends and Inequities Related to Atherosclerotic Cardiovascular Disease and Stroke Among Adults in the U.S., 1999–2025
Background
Atherosclerotic cardiovascular disease and stroke are leading causes of death in the United States, with overlapping risk factors and significant public health implications. Recent analyses indicate that while mortality rates have declined, this progress has been inconsistent, particularly among younger adults and marginalized populations.
Data Highlights
Year
Age-Adjusted Mortality Rate (AAMR) per 100,000
1999
26.82
2025
10.91
Key Findings
Overall average AAMR for ASCVD and stroke-related conditions was 15.01 per 100,000.
Mortality rates declined from 26.82 in 1999 to 10.91 per 100,000 in 2025, with an annual percentage change (AAPC) of 3.53% (p < 0.001).
A borderline significant increase in mortality was observed from 2018 to 2021 (APC: 6.06%; p = 0.050).
Mortality burden was higher among men, older adults, Black individuals, and residents of the South.
Adults aged 2544 years showed a significant increase in mortality rates after 2015.
Clinical Implications
Healthcare professionals should be aware of the persistent disparities in ASCVD and stroke mortality, particularly among younger adults and marginalized populations. Enhanced prevention strategies are necessary to address these inequities and improve outcomes.
Conclusion
While there has been a significant decline in mortality related to ASCVD and stroke from 1999 to 2025, the observed disparities and recent increases during the pandemic period are noted.
