Hyperthermia enhances the efficacy of PD-1 inhibitor plus chemotherapy in PD-L1 CPS-negative advanced gastric cancer
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By
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Weihang Li
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Xin Sun
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Ping Li
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Ting Wang
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Panling Xu
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May 13, 2026
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Clinical Report: The Role of Hyperthermia in Improving Outcomes of PD-1 Inhibitor and Chemotherapy for Advanced Gastric Cancer with Negative PD-L1 CPS
Overview
{'adverse_effects': 'Specify which adverse effects were reduced.'}
Background
{'treatment_limitations': 'Expand on the limitations of current treatments for PD-L1 CPS-negative patients.'}
Data Highlights
{'statistical_significance': 'Ensure all findings include clear statistical significance.'}
Key Findings
{'CTC_context': 'Provide context on the implications of increased CTC numbers.'}
Clinical Implications
{'specific_populations': 'Identify specific patient populations that may benefit.'}
Conclusion
{'further_studies': 'Highlight the necessity for further validation studies.'}
Related Resources & Content
- The ASCO Post, 2017 -- Hyperthermic Intraperitoneal Chemoperfusion May Be Efficacious for Peritoneal Metastases Novel Therapy for Stage IV Gastric Cancer Related Articles
- The ASCO Post, 2021 -- Study Suggests Lack of Benefit With the Addition of Immune Checkpoint Inhibition to Chemotherapy in Low PD-L1–Expressing Gastric or Esophageal Adenocarcinoma
- Frontiers in Immunology, 2026 -- Multi-omics biomarkers for predicting resistance, hyperprogression, and immune-related toxicity during PD-1/PD-L1 therapy in lung cancer: a literature review
- FDA Briefing Document, 2024 -- Errata to FDA Briefing Document - Gastric and Gastroesophageal Junction Adenocarcinoma
- Frontiers, 2025 -- From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy
- NCCN Clinical Practice Guidelines In Oncology, 2025 -- Gastric Cancer, Version 2.2025
- The ASCO Post — Less Is More: No Benefit Reported for Hyperthermic Intraperitoneal Chemotherapy in Colorectal Cancer
- Errata to FDA Briefing Document - Gastric and Gastroesophageal Junction Adenocarcinoma
- Frontiers | From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy
- Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology - PubMed
