Precision for all children: embedding equity into precision medicine for children - Report - MDSpire

Precision for all children: embedding equity into precision medicine for children

  • By

  • Victor Do

  • Justin Lam

  • Sanjay Mahant

  • Eyal Cohen

  • Indra Narang

  • Astrid Guttmann

  • Damien Noone

  • July 2, 2026

  • 0 min

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Clinical Report: Ensuring Equity in Precision Medicine for Pediatric Care

Background

Precision medicine has the potential to enhance healthcare outcomes by tailoring treatments based on individual genetic and environmental factors. However, many children, particularly from marginalized backgrounds, continue to experience significant barriers to accessing these advancements. Addressing these inequities is crucial to ensure that the benefits of precision medicine are distributed fairly across all pediatric populations.

Data Highlights

No numerical data available in the source material.

Key Findings

  • Precision medicine initiatives in pediatrics have largely focused on genomic technologies and targeted therapies.
  • Many children globally face barriers to accessing necessary healthcare services, medications, and preventive care.
  • Structural inequities influence who can access genetic testing and emerging therapies.
  • Historical mistrust and exploitation contribute to hesitance among marginalized families to engage in precision medicine initiatives.
  • Without intentional equity measures, advancements in precision medicine may exacerbate existing health disparities.
  • There is a need for a Precision Child Health Equity framework that incorporates social, structural, and environmental factors affecting health.

Clinical Implications

Healthcare providers must recognize and address the systemic barriers that prevent equitable access to precision medicine for all children.

Conclusion

A comprehensive approach that includes social determinants of health is necessary for meaningful progress.

Related Resources & Content

  1. The ASCO Post, 2020 -- Precision Medicine Is Becoming a Reality for Pediatric Patients With Cancer
  2. The ASCO Post, 2017 -- Ensuring Equitable Cancer Care for All Patients
  3. Clinical report outlines how, why to pursue genetic diagnosis for GDD/ID | AAP News | American Academy of Pediatrics
  4. Operationalizing Equity: A Methodologic Framework for Revising Pediatric Clinical Guidance | Pediatrics | American Academy of Pediatrics
  5. The ASCO Post — Ensuring Equitable Cancer Care for All Patients
  6. Frontiers in Oncology — Developing a multidisciplinary pediatric cancer predisposition service at a mid-sized children’s hospital
  7. Clinical report outlines how, why to pursue genetic diagnosis for GDD/ID | AAP News | American Academy of Pediatrics
  8. Operationalizing Equity: A Methodologic Framework for Revising Pediatric Clinical Guidance | Pediatrics | American Academy of Pediatrics
  9. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update - PMC
  10. Diagnostic and clinical utility of exome sequencing and chromosomal microarray in children with GDD/iD: a meta-analysis - PubMed
  11. Rapid Genome Sequencing Compared with a Gene Panel in Critically Ill Infants with a Suspected Genetic Disorder: An Economic Evaluation - PubMed
  12. Toward Same-Day Genome Sequencing in the Critical Care Setting | New England Journal of Medicine
  13. Implementing customized genomic sequencing reports to empower providers in safety-net neonatal intensive care units - ScienceDirect
  14. Germline Cancer Predisposition Results From the National Cancer Institute—Children's Oncology Group Pediatric MATCH Trial | JCO Precision Oncology
  15. Comprehensive Genomic Characterization of Congenital and Infantile Cancers Reveals High Yield of Medically Meaningful Findings | JCO Precision Oncology

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