Clinical Report: Early Identification of Infected Pancreatic Necrosis

Background

Infected pancreatic necrosis (IPN) is a serious complication of severe acute pancreatitis (SAP) that significantly increases mortality risk. The development of IPN is a critical event that can occur after the second week of illness. The co-occurrence of IPN with abdominal compartment syndrome complicates management. This case highlights the challenges faced in managing polymicrobial infections in critically ill patients.

Data Highlights

No numerical data or trial data available in the article.

Key Findings

• A 51-year-old male with severe acute pancreatitis developed infected pancreatic necrosis.
• Blood cultures revealed Enterococcus faecium and Enterococcus faecalis.
• Infected pancreatic necrosis was confirmed on day 7, with concurrent carbapenem-resistant Acinetobacter baumannii infection.
• The patient was treated with sulbactam-durlobactam and tigecycline.
• After a 10-day course of treatment, the patient was discharged in stable condition on day 75.

Clinical Implications

This case illustrates the importance of early identification of infected pancreatic necrosis in patients with severe acute pancreatitis. The use of sulbactam-durlobactam combined with tigecycline may be a viable treatment option for infections caused by multidrug-resistant organisms.

Conclusion

The successful management of this case underscores the need for tailored antimicrobial regimens in the presence of multidrug-resistant infections. Early intervention in suspected infected pancreatic necrosis is crucial for improving patient outcomes.

Related Resources & Content

1. Frontiers in Medicine, 2026 -- Microbiological Eradication of XDR Acinetobacter baumannii Intra-abdominal Infection using Sulbactam-Durobactam: Clinical and Microbiological Outcomes Amidst Irreversible Host Comorbidities
2. Infection, 2024 -- Evaluation of Sulbactam's Effectiveness in Managing Infections Caused by Extensively Drug-Resistant Acinetobacter baumannii: A Retrospective Analysis
3. International Journal of Infectious Diseases, 2024 -- In vitro activity of cefiderocol and sulbactam-durlobactam against clinical-isolated carbapenem-resistant Acinetobacter baumannii from China
4. Gut, 2012 -- Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus
5. International Journal of Infectious Diseases — Successful eravacycline monotherapy for cefiderocol-resistant Acinetobacter baumannii bloodstream infection in a critically ill patient with concomitant Clostridioides difficile colitis
6. Natural History and Microbiological Profiles of Patients With Acute Pancreatitis With Suspected Infected Pancreatic Necrosis
7. IDSA 2024 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
8. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus | Gut