Factors associated with cognitive developmental delay risk in 12-month-old infants - Report - MDSpire

Factors associated with cognitive developmental delay risk in 12-month-old infants

  • By

  • Yanping Zhang

  • Wei Li

  • Xiaochun He

  • Xiu Wang

  • Haoyue Gao

  • Jing Zeng

  • June 22, 2026

  • 0 min

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Clinical Report: Identifying Risk Factors for Cognitive Developmental Delays in Infants

Overview

This study identifies multiple risk factors associated with cognitive developmental delays in 12-month-old infants.

Background

Cognitive development in infancy is crucial for long-term mental health and social adaptation. Delayed cognitive development can lead to academic difficulties and increased risk of mental health issues later in life.

Data Highlights

Risk FactorOdds Ratio (OR)95% Confidence Interval (CI)
Cesarean delivery1.421.05–1.93
Maternal alcohol use during pregnancy9.121.09–76.33
Pre-pregnancy overweight1.621.02–2.58
Pre-pregnancy obesity2.541.08–5.95
Inadequate gestational weight gain4.091.74–9.62
Excessive gestational weight gain1.591.10–2.29
Grandparental caregiving1.801.32–2.46
Higher paternal education (postgraduate or above)0.060.01–0.56
Annual household income > 300,000 CNY0.310.12–0.80

Key Findings

  • Cesarean delivery is associated with a higher risk of cognitive developmental delays (OR = 1.42).
  • Maternal alcohol use during pregnancy significantly increases risk (OR = 9.12).
  • Pre-pregnancy overweight and obesity are linked to higher odds of developmental delays (OR = 1.62 and OR = 2.54, respectively).
  • Both inadequate and excessive gestational weight gain are independent risk factors (OR = 4.09 and OR = 1.59, respectively).
  • Grandparental caregiving is associated with increased risk (OR = 1.80).
  • Higher paternal education and higher household income are protective factors (OR = 0.06 and OR = 0.31, respectively).

Clinical Implications

Healthcare providers should consider these identified risk factors when assessing infants for cognitive developmental delays. Early screening and targeted interventions may be warranted based on maternal health, delivery mode, and caregiving arrangements.

Conclusion

The study highlights the importance of a comprehensive assessment of various risk factors to identify infants at risk for cognitive developmental delays. Early intervention strategies can be informed by these findings.

Related Resources & Content

  1. European Radiology, 2025 -- Impact of Cerebellar Hemorrhage in Extremely Preterm Infants: Correlation of Dentate Nucleus Involvement and Cerebellar Hypoplasia with Negative Cognitive Outcomes
  2. JAMA Network Open, 2025 -- Maternal Intellectual and Developmental Disabilities and Infant Outcomes
  3. The Journal of Clinical Endocrinology & Metabolism, 2025 -- Link Between Reduced Maternal Sleep Duration and Neurodevelopmental Delays in Children: Findings from a Prospective Cohort Study
  4. Frontiers in Pediatrics, 2026 -- Multivariate Risk Assessment and Analysis of Brain Injury in High-Risk Infants in Neonatal Intensive Care Unit
  5. Preventive Care/Periodicity Schedule -- American Academy of Pediatrics
  6. The prevalence of long-term neurodevelopmental outcomes in preterm-born children in low- and middle-income countries: a systematic review and meta-analysis of developmental outcomes in 72 974 preterm-born children, 2025
  7. Umbrella Review and Meta-Analysis: Screening Tools for the Identification of Developmental Delay in Early Childhood
  8. Preventive Care/Periodicity Schedule
  9. The prevalence of long-term neurodevelopmental outcomes in preterm-born children in low- and middle-income countries: a systematic review and meta-analysis of developmental outcomes in 72 974 preterm-born children

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