Prognostic Indicators and Clinical Characteristics of Brain Metastases in Ovarian Cancer: A Retrospective Analysis of 129 Cases Across Multiple Centers

By
Yingying Wang
Qiyue Chao
Xiaoyan Lu
Yichi Zhou
Zhiwen Xie
Shiyun Zhang
Fei Xu
Sikao Wu
Lvzhong Hu
Bo Ding
Xinyi Zhang
Tianmin Xu
Guantai Ni
Jing Liang
Jinhua Zhou
Yang Shen
Bo Yang
Shengtao Zhou
Xiaojun Chen
Tingyan Shi
Chunyan Lan
Tao Zhu
Ying Zhou
November 7, 2025
0 min

Bmc Cancer

Overview

This study analyzes 129 cases of brain metastases in ovarian cancer, revealing a 5-year overall survival rate of 29.2%. It highlights the need for standardized treatment protocols and the potential role of precision medicine in improving outcomes.

Background

Brain metastases in ovarian cancer are rare but significantly impact patient survival and quality of life. Current treatment strategies are often adapted from other cancers due to the lack of standardized protocols, which complicates patient management. Understanding the clinical characteristics and prognostic indicators of these patients is crucial for enhancing treatment approaches.

Data Highlights

Characteristic	Value
Number of Patients	129
5-Year Overall Survival Rate	29.2%
Patients with Family History of Cancer	24.8%
BRCA Pathogenic Mutations Identified	15.8%
Patients Receiving PARPi Therapy	14.0%

Key Findings

Brain metastases occur in 2.5%–6.0% of ovarian cancer patients.
The median interval from ovarian cancer diagnosis to brain metastasis was 25.7 months.
Multiple lesions and higher CA-125 levels correlate with worse survival outcomes.
Stereotactic radiosurgery (SRS) is associated with better survival compared to other treatment modalities.
Only 10.8% of patients were diagnosed at FIGO stage I and II, indicating late-stage presentation.

Clinical Implications

Healthcare providers should consider the unique characteristics of brain metastases in ovarian cancer when developing treatment plans. The findings suggest that SRS may be a preferred treatment option for patients with limited lesions, potentially improving survival outcomes.

Conclusion

This study underscores the importance of understanding the clinical features and prognostic indicators of brain metastases in ovarian cancer to enhance patient management and treatment strategies.

Prognostic Indicators and Clinical Characteristics of Brain Metastases in Ovarian Cancer: A Retrospective Analysis of 129 Cases Across Multiple Centers