Assessing the efficacy of ultrasound-guided platelet-rich plasma on nerve regeneration and functional outcomes in forearm peripheral nerve injuries: a retrospective observational study - Report - MDSpire

Assessing the efficacy of ultrasound-guided platelet-rich plasma on nerve regeneration and functional outcomes in forearm peripheral nerve injuries: a retrospective observational study

  • By

  • Qing Li

  • Cong Zou

  • Wenjie Liu

  • Lingling Zuo

  • Hui Long

  • Wei Gao

  • Bin Liu

  • July 6, 2026

  • 0 min

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Clinical Report: Evaluating the Impact of Ultrasound-Guided PRP Therapy on Nerve Regeneration

Overview

This study assesses the efficacy of ultrasound-guided platelet-rich plasma (PRP) therapy in enhancing nerve regeneration and functional recovery in patients with forearm peripheral nerve injuries. Results indicate improvements in nerve cross-sectional measurements and functional outcomes compared to conventional rehabilitation.

Background

Peripheral nerve injuries can lead to long-term disability and impact quality of life. Current treatments often yield suboptimal recovery.

Data Highlights

OutcomePRP GroupConventional GroupP-value
Nerve Cross-Sectional DiameterIncreasedDecreased0.021
Nerve Cross-Sectional AreaIncreasedDecreased0.004
DASH ScoresLowerHigher0.008
Sensory Conduction VelocityHigherLower0.042
Motor Conduction VelocityHigherLower0.044
Serum BDNF LevelsIncreasedNot Reported0.006
Serum NGF LevelsIncreasedNot Reported0.002
Serum NT-3 LevelsIncreasedNot Reported0.007

Key Findings

  • The PRP group had a significantly larger nerve cross-sectional diameter compared to the conventional group (p = 0.021).
  • The PRP group exhibited a significantly larger nerve cross-sectional area (p = 0.004).
  • DASH scores were significantly lower in the PRP group at 2 months post-treatment (p = 0.008).
  • Higher sensory conduction velocity was observed in the PRP group (p = 0.042).
  • Motor conduction velocity was also significantly higher in the PRP group (p = 0.044).
  • Serum levels of BDNF, NGF, and NT-3 were significantly elevated in the PRP group (all p < 0.05).

Clinical Implications

The findings indicate that ultrasound-guided PRP therapy may enhance nerve regeneration and improve functional recovery in patients with forearm peripheral nerve injuries.

Conclusion

Ultrasound-guided PRP therapy improves nerve regeneration and functional outcomes in patients with forearm peripheral nerve injuries compared to conventional rehabilitation alone.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Ultrasound predictors of peripheral nerve block failure after blast injury: a prospective cohort study
  2. conexiant -- PRP Linked to Better Outcomes in Advanced Knee OA
  3. Comparative Analysis of Nerve Transfer Techniques for Restoring Elbow Flexion in Brachial Plexus Injuries: A Systematic Review
  4. glaucoma physician -- PRP Treatment in the Clinic
  5. Guideline for traumatic median and ulnar nerve injuries in the forearm, 2025
  6. BMCanesthesiol -- PRP for peripheral nerves, 2025
  7. https://register.awmf.org/assets/guidelines/005-010l_S3_Versorgung-peripherer-Nervenverletzungen_2025-02.pdf
  8. https://bmcanesthesiol.biomedcentral.com/counter/pdf/10.1186/s12871-025-03257-x.pdf
  9. | www.nature.com/scientificreports --- | ---OPEN

Original Source(s)

Assessing the efficacy of ultrasound-guided platelet-rich plasma on nerve regeneration and functional outcomes in forearm peripheral nerve injuries: a retrospective observational study

  • by Qing Li, Cong Zou, Wenjie Liu, Lingling Zuo, Hui Long, Wei Gao, Bin Liu

  • July 6, 2026

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