Gestational Age as predictor of Postoperative Prognosis in Neonates with Pulmonary Atresia With Intact Ventricular Septum Undergoing Biventricular Repair - Report - MDSpire

Gestational Age as predictor of Postoperative Prognosis in Neonates with Pulmonary Atresia With Intact Ventricular Septum Undergoing Biventricular Repair

  • By

  • Chen, Shuo

  • Zhou, Ziqin

  • Hu, Luoming

  • tu, jiazichao

  • chen, weimin

  • tian, miao

  • Deng, Xiaohua

  • Li, Xiaohua

  • Su, Zhanhao

  • Chen, Jimei

  • June 22, 2026

  • 0 min

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Gestational Age as a Prognostic Indicator for Postoperative Outcomes in Neonates

Overview

This study investigates the impact of gestational age on short-term outcomes in neonates with pulmonary atresia and intact ventricular septum undergoing biventricular repair. Findings indicate that each additional gestational week reduces the risk of adverse outcomes significantly, with a notable threshold effect at 37.6 weeks.

Background

Pulmonary atresia with intact ventricular septum (PA/IVS) is a critical congenital heart defect with variable surgical outcomes. Understanding prognostic factors like gestational age is essential for optimizing surgical strategies and improving patient management. This study aims to clarify the relationship between gestational age and postoperative outcomes in this patient population.

Data Highlights

Gestational AgeAdverse Outcome Risk
Each additional week45% reduction (OR 0.55, 95% CI 0.41-0.75)
Term vs PretermSignificantly lower risk (OR 0.14, 95% CI 0.04-0.46)
Threshold at 37.6 weeks92% lower risk (OR 0.08, 95% CI 0.02-0.42)

Key Findings

  • Gestational age is a significant prognostic factor for postoperative outcomes in PA/IVS.
  • Each additional week of gestation reduces the risk of adverse outcomes by 45%.
  • Term infants have a significantly lower risk of complications compared to preterm infants.
  • A nonlinear threshold effect for gestational age was identified at 37.6 weeks.
  • Infants born beyond 37.6 weeks have a 92% lower risk of adverse outcomes.

Clinical Implications

Gestational age should be considered when planning surgical interventions for neonates with PA/IVS.

Conclusion

This study highlights the importance of gestational age in predicting short-term outcomes for neonates undergoing biventricular repair for PA/IVS.

Related Resources & Content

  1. Pediatric Cardiology, 2023 -- The Impact of Gestational Age and Size on Treatment Approaches and Outcomes in Symptomatic Neonatal Tetralogy of Fallot
  2. Pediatric Cardiology, 2016 -- Outcomes of Surgical Intervention for Ventricular Septal Defect: Current Findings and Associated Complication Risk Factors
  3. Pediatric Cardiology, 2025 -- Reassessing the Viability of Biventricular Repair in Prenatal Consultations: An Analysis of Fetal Echocardiographic Findings in Candidates for Complex Biventricular Surgery
  4. 2025 American Association for Thoracic Surgery Congenital Cardiac Surgery Working Group -- Expert consensus document on the management of patients with pulmonary atresia with intact ventricular septum
  5. Pediatric Cardiology — Effects of Prematurity on Health Outcomes and Survival Rates in Newborns Diagnosed with Dextro-transposition of the Great Arteries
  6. Pulmonary Atresia With Intact Ventricular Septum - StatPearls
  7. Gestational age at birth and outcomes after neonatal cardiac surgery
  8. 2025 American Association for Thoracic Surgery Congenital Cardiac Surgery Working Group— Expert consensus document on the management of patients with pulmonary atresia with intact ventricular septum - ScienceDirect
  9. Critical congenital heart disease in extreme prematurity: Surgical outcomes from a specialized neonatal cardiac intensive care unit - ScienceDirect
  10. Relationship between gestational age and outcomes after congenital heart surgery - PMC
  11. Part 8: Pediatric Advanced Life Support: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care | Pediatrics | American Academy of Pediatrics
  12. Tailored preoperative assessment in neonatal cardiac surgery: a European Congenital Heart Surgeons Association study‡ - PubMed
  13. The Society of Thoracic Surgeons Congenital Heart Surgery Database Mortality Risk Model: Part 1—Statistical Methodology - PMC

Original Source(s)

Gestational Age as predictor of Postoperative Prognosis in Neonates with Pulmonary Atresia With Intact Ventricular Septum Undergoing Biventricular Repair

  • by Chen, Shuo , Zhou, Ziqin , Hu, Luoming , tu, jiazichao , chen, weimin , tian, miao , Deng, Xiaohua , Li, Xiaohua , Su, Zhanhao , Chen, Jimei

  • June 22, 2026

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