Diagnostic inflation in autism spectrum disorder: an epistemological and methodological reappraisal - Report - MDSpire

Diagnostic inflation in autism spectrum disorder: an epistemological and methodological reappraisal

  • By

  • Luigi Croce

  • Irene Fusaro

  • July 6, 2026

  • 0 min

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Clinical Report: Reevaluating Diagnostic Trends in Autism Spectrum Disorder

Overview

This narrative review critically examines the rising prevalence of Autism Spectrum Disorder (ASD) and current diagnostic practices.

Background

The prevalence of ASD has increased significantly, raising questions about the coherence of the DSM-5 diagnostic category. This review addresses the complexities of diagnosing ASD, particularly in adults, where overlapping features with other psychiatric conditions complicate accurate identification.

Data Highlights

No numerical or trial data presented in the article.

Key Findings

  • The ASD category includes at least two neurobiologically distinct phenotypes: Type I (prototypical, syndromic) and Type II (milder, polygenically driven).
  • The DSM-5 sensory criterion lacks diagnostic specificity.
  • Current assessment models are inadequate for capturing the complexities of the female phenotype in ASD.
  • Six minimum evidentiary standards for adult ASD differential diagnosis are proposed.
  • Specialized pathways for differential diagnosis should utilize multidisciplinary triage.

Clinical Implications

Clinicians should adopt the proposed minimum standards for ASD diagnosis to enhance accuracy and reduce misdiagnosis. Implementing a multidisciplinary approach can facilitate better identification of ASD and appropriate intervention pathways.

Conclusion

This review emphasizes the need for rigorous diagnostic standards in the context of evolving understandings of autism.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Frontiers in Psychiatry, 2026 -- Getting the timing right. Autistic adolescents reflect on the value of an early diagnosis
  3. Frontiers in Psychiatry, 2026 -- Comparative analysis of diagnostic expectations between adults referred for ADHD and autism assessment: a thematic analysis
  4. JAMA Network Open -- Innovation to Improve Detection of Early Developmental and Behavioral Concerns
  5. American Psychiatric Association, DSM-5-TR -- Autism Spectrum Disorder
  6. CDC, 2022 -- Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years
  7. United States Preventive Services Taskforce -- Recommendation: Autism Spectrum Disorder in Young Children: Screening
  8. Autism Spectrum Disorder
  9. Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years — Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022 | MMWR
  10. Recommendation: Autism Spectrum Disorder in Young Children: Screening | United States Preventive Services Taskforce

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