Neglecting to Revise ClinicalTrials.gov Entry for a Research Study
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By
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Dost Ongur
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September 1, 2026
Neglecting to Revise ClinicalTrials.gov Entry for a Research Study
Background
Accurate and timely updates to clinical trial registries like ClinicalTrials.gov are essential for maintaining transparency and trust in clinical research. Delays in updating trial records can lead to misconceptions about the integrity of study findings.
Data Highlights
No numerical data provided in the source material.
Key Findings
- The trial registered on ClinicalTrials.gov in April 2018 but had significant revisions in March 2025.
- Revisions included changes to primary outcomes, inclusion/exclusion criteria, and planned sample size.
- Protocol modifications were approved by the institutional review board and published in a peer-reviewed journal in 2021.
- Concerns arose regarding the timing of protocol updates and their implications for trial integrity.
- The authors acknowledged the error of not updating the ClinicalTrials.gov record in real time.
Clinical Implications
Healthcare professionals should be aware of the importance of updates to clinical trial registries.
Conclusion
Ensuring accurate and prompt updates is crucial for maintaining the credibility of clinical research.
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- Clozapine After 1 Failed Antipsychotic Drug Trial in First-Episode Psychosis: A Randomized Clinical Trial | Trials | JAMA Psychiatry | JAMA Network
- Efficacy of clozapine versus second-generation antipsychotics in people with treatment-resistant schizophrenia: a systematic review and individual patient data meta-analysis - PubMed
- Failure to Update ClinicalTrials.gov Record for a Clinical Trial | Psychiatry and Behavioral Health | JAMA Psychiatry | JAMA Network
- Frequently Asked Questions | ClinicalTrials.gov
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- Clinical Trial Reporting Requirements | ClinicalTrials.gov
Based on findings from:
Failure to Update ClinicalTrials.gov Record for a Clinical Trial
Dost Ongur. Jama Psychiatry, 2026.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2852239
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
