Clinical Report: Pediatric Hodgkin Lymphoma Associated with Hypereosinophilia
Overview
This report presents a rare case of a 17-year-old female with classical Hodgkin lymphoma (HL) exhibiting profound hypereosinophilia. The case underscores the need for awareness of HL in patients with unexplained eosinophilia, particularly in pediatric populations.
Background
Hodgkin lymphoma is a significant pediatric malignancy, comprising 6% of childhood cancers. Hypereosinophilia, while observed in 15% of HL cases, is rarely profound, making this case particularly noteworthy. Understanding the association between HL and eosinophilia is crucial for timely diagnosis and treatment.
Data Highlights
Parameter
Value
Eosinophil Count
97,880/µL (93.3% of WBC)
Hemoglobin
10.49 g/dL
Hematocrit
34.5%
LDH Level
201 U/L
Albumin
2.90 g/dL
Key Findings
A 17-year-old female presented with significant weight loss, night sweats, and hypereosinophilia.
Laboratory tests revealed eosinophilia of 97,880/µL, constituting 93.3% of total leukocytes.
Bone marrow biopsy confirmed eosinophilic predominance, while lymph node biopsy diagnosed nodular sclerosis classical Hodgkin lymphoma.
Initial treatment with OEPA/COPDAC resulted in an incomplete metabolic response, followed by successful radiotherapy.
Marked decline in eosinophil counts was observed post-therapy, highlighting the relationship between HL and eosinophilia.
Clinical Implications
Clinicians should consider Hodgkin lymphoma in differential diagnoses for patients presenting with unexplained hypereosinophilia, particularly in adolescents. Early recognition and treatment can lead to improved outcomes, as demonstrated in this case.
Conclusion
This case illustrates the rare but significant association between classical Hodgkin lymphoma and profound hypereosinophilia, emphasizing the importance of considering oncologic causes in patients with eosinophilia.
by Rosa Margarita Cruz Osorio, Regina M. Navarro-Martin del Campo, Wangky Carolina Carrasco-Rivera, Lisette Paola Bruijnzeels-Ponce, Jesús Alejandro Gutiérrez-Ortiz, Hannali Quintero-Buenrostro, Violeta Salceda-Rivera, Manuel Donovan Martinez-Albarran, Diego Ugalde-Aviña, Veronica Soto Chavez, Fernando Sánchez-Zubieta, Oscar Gonzalez-Ramella
