Clinical Report: Impact of Lidocaine on Postoperative Pain Management Following MRM

Overview

This study evaluates the analgesic effect of intravenous lidocaine on postoperative pain in patients undergoing modified radical mastectomy. Results indicate that lidocaine significantly reduces pain scores and inflammatory markers compared to control groups.

Background

Postoperative pain management is critical for patients undergoing modified radical mastectomy, as inadequate pain control can lead to prolonged recovery and chronic pain. Intravenous lidocaine has emerged as a potential adjunct in multimodal analgesia, offering benefits such as reduced opioid consumption and improved pain outcomes. Understanding its efficacy in this context is essential for optimizing postoperative care.

Data Highlights

Key Findings

• Lidocaine infusion significantly reduced resting and active NRS scores at 24 hours postoperatively compared to controls.
• Lower NRS scores were observed at 3, 6, and 12 hours after surgery in lidocaine groups.
• Postoperative inflammatory markers (IL-6, IL-1β, TNF-α, NF-κB) were significantly lower in lidocaine groups.
• No significant differences in anesthetic and analgesic consumption or patient satisfaction were noted among all groups.
• The benefits of lidocaine were independent of the type of maintenance anesthesia used (sevoflurane vs. propofol).

Clinical Implications

The use of intravenous lidocaine during modified radical mastectomy can enhance postoperative pain management and reduce inflammatory responses. This approach may facilitate recovery and decrease reliance on opioids, aligning with current multimodal analgesia strategies.

Conclusion

Intravenous lidocaine is a promising adjunct for managing postoperative pain in modified radical mastectomy patients, warranting further investigation to confirm its long-term benefits and mechanisms.

Related Resources & Content

1. Frontiers | Effect of Lidocaine on Acute Pain After Modified Radical Mastectomy: A Secondary Analysis of a Randomized Trial
2. Techniques in Coloproctology — Intravenous Lidocaine Infusion for Managing Postoperative Pain and Enhancing Recovery in Adult Patients
3. Drugs - Real World Outcomes — Efficacy of Intravenous Lidocaine in Managing Acute Pain: A Retrospective Analysis from One Institution
4. Techniques in Coloproctology — Efficacy of Intravenous Lidocaine for Alleviating Post-Surgical Pain Following Hand-Assisted Laparoscopic Colon Surgery: A Randomized, Placebo-Controlled Study
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8. Frontiers | Perioperative intravenous lidocaine for postoperative pain in patients undergoing breast surgery: a meta-analysis with trial sequential analysis of randomized controlled trials
9. Frontiers | Effect of Lidocaine on Acute Pain After Modified Radical Mastectomy: A Secondary Analysis of a Randomized Trial