Predictive Role of Serum Citrullinated Histone H3 and TSLP in Wound Healing

Overview

This study investigates the prognostic value of serum citrullinated histone H3 (CitH3) and thymic stromal lymphopoietin (TSLP) in postoperative wound healing after Bascom cleft lift surgery for pilonidal sinus disease. A nomogram-based risk assessment model was developed, demonstrating strong predictive capabilities for wound healing outcomes.

Background

Pilonidal sinus disease is a common condition affecting primarily young, overweight males, leading to significant morbidity. Effective postoperative wound healing is crucial for patient recovery and reducing recurrence rates. Identifying biomarkers that predict healing outcomes can enhance clinical decision-making and patient management.

Data Highlights

Key Findings

• Wound healing dysfunction occurred in 14.36% of patients.
• Higher levels of BMI, FBG, CRP, CitH3, and TSLP were associated with poor healing outcomes.
• Serum CitH3 and TSLP levels were positively correlated in the poor-healing cohort (r = 0.562).
• The nomogram showed AUCs of 0.958 in the training cohort and 0.970 in the validation cohort.
• Increased ALB levels were identified as a protective factor against poor healing.

Clinical Implications

Clinicians should consider preoperative serum levels of CitH3 and TSLP as potential indicators of wound healing outcomes in patients undergoing Bascom cleft lift surgery. The developed nomogram may serve as a useful tool for personalized risk assessment and management strategies.

Conclusion

Elevated serum CitH3 and TSLP levels are significantly linked to compromised wound healing following surgery for pilonidal sinus disease. The nomogram developed in this study holds promise for enhancing clinical decision-making, pending further validation.

References

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