Clinical Report: Analysis of Global Research Trends in Colorectal Cancer Organoids

Overview

This bibliometric study analyzes the growth and trends in colorectal cancer organoid research from 2010 to 2025, highlighting key contributors and emerging research hotspots. The findings indicate a shift towards high-fidelity disease models and personalized cancer therapies.

Background

Colorectal cancer remains a significant global health challenge, necessitating innovative research approaches to improve treatment outcomes. Organoids, as patient-derived models, offer a promising avenue for studying tumor biology and testing therapeutic responses. Understanding research trends in this area can inform future studies and clinical applications.

Data Highlights

Key Findings

• 2239 publications related to colorectal cancer organoids were identified from 2010 to 2025.
• China and the United States are the leading contributors to this research field.
• Utrecht University was the most productive institution in terms of publications.
• Hans Clevers is noted for having the highest total citations and number of publications.
• The journal 'Cancers' was the most productive, while 'Nature' was the most frequently cited.
• Current research hotspots include drug screening, tumor microenvironment, tumor immunity, and precision oncology.

Clinical Implications

The findings suggest that colorectal cancer organoids are becoming integral to the development of personalized treatment strategies. Clinicians should consider the implications of these models in understanding tumor behavior and therapeutic responses, potentially leading to improved patient outcomes.

Conclusion

The study underscores the rapid evolution of colorectal cancer organoid research, emphasizing its potential in precision oncology. Continued exploration in this area is essential for advancing clinical applications and improving cancer management.

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10. Patient-Derived Organoids Predict Treatment Response in Metastatic Colorectal Cancer | Clinical Cancer Research | American Association for Cancer Research