TyG-ABSI: A New Indicator of Metabolic Obesity for Carotid Plaque Evaluated Through Explainable Machine Learning in a Low-Income Population - Report - MDSpire

TyG-ABSI: A New Indicator of Metabolic Obesity for Carotid Plaque Evaluated Through Explainable Machine Learning in a Low-Income Population

  • By

  • Juan Hao

  • Ran Chen

  • Diliyaer Abudukeremu

  • Xiao Li

  • Yiwei Zhang

  • Lifeng Wang

  • Chenxi Fan

  • Chunsheng Yang

  • Xianjia Ning

  • Jinghua Wang

  • Yan Li

  • December 16, 2025

  • 0 min

Share

Clinical Report: TyG-ABSI as a Predictor of Carotid Plaque in Low-Income Populations

Overview

This study introduces the TyG-ABSI index as a novel predictor of carotid plaque in low-income rural populations, utilizing machine learning and SHAP visualization. The findings suggest that integrating TyG-ABSI can enhance risk assessment for cardiovascular disease in underserved communities.

Background

Incorporate statistics on obesity and insulin resistance in low-income populations.

Data Highlights

No numerical data available in the provided material.

Key Findings

  • The TyG-ABSI index is proposed as a new indicator for predicting carotid plaque risk.
  • Machine learning techniques, particularly SHAP visualization, enhance the interpretability of risk factors in complex datasets.
  • Carotid plaque affects 21.1% of adults globally and is linked to increased CVD risk.
  • Obesity and insulin resistance are significant contributors to carotid plaque formation.
  • Low-income populations exhibit a disproportionate burden of CVD, necessitating tailored preventive strategies.

Clinical Implications

Integrating the TyG-ABSI index into routine assessments could improve the identification of individuals at risk for carotid plaque in low-income settings. This approach may facilitate early intervention and targeted prevention efforts to reduce the incidence of cerebrovascular diseases.

Conclusion

The study highlights the potential of TyG-ABSI as a valuable tool for predicting carotid plaque in underserved populations, emphasizing the need for innovative approaches to address cardiovascular health disparities.

References

  1. Frontiers in Endocrinology, 2026 -- Links Between Cholesterol, High-Density Lipoprotein, Glucose Index, and Triglyceride-Glucose Indices with Carotid Atherosclerosis in Young and Middle-Aged Adults
  2. Obesity Surgery, 2018 -- Impact of Type 2 Diabetes Mellitus on Subclinical Atherosclerosis in Individuals with Severe Obesity
  3. The Journal of Clinical Endocrinology & Metabolism, 2025 -- The Role of Adipokines in Changes in Metabolic Health Over Time: Insights from the Atherosclerosis Risk in Communities (ARIC) Study
  4. 2024 Guideline for the Primary Prevention of Stroke - Professional Heart Daily | American Heart Association
  5. The Journal of Clinical Endocrinology & Metabolism — Influence of Intermuscular Fat in the Abdomen and Thigh on Glucose Regulation and Cardiometabolic Risk Among Obese Adults
  6. Asymptomatic Carotid Surgery Trial - American College of Cardiology
  7. Relationship between triglyceride-glucose index and carotid artery plaques in ischemic stroke patients
  8. 2024 Guideline for the Primary Prevention of Stroke - Professional Heart Daily | American Heart Association

Original Source(s)

Related Content