Schistosomiasis: A Persistent Endemic Challenge Since Ancient Egyptian Times - Report - MDSpire

Schistosomiasis: A Persistent Endemic Challenge Since Ancient Egyptian Times

  • By

  • Ahmed Ramadan

  • F. Sabry

  • Ahmed M. Gaheen

  • Amr EL Rabat

  • El-Malky Mohamed

  • Abdelaleem Helal

  • M. Eissa

  • Shaimaa A. Farag

  • Gamal A. Badra

  • Marwa El fayoumy

  • January 10, 2026

  • 0 min

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Clinical Report: Schistosomiasis: A Persistent Endemic Challenge Since Ancient Egyptian Times

Overview

Schistosomiasis remains a significant public health challenge in Egypt, with S. mansoni being the predominant species causing severe intestinal and hepatobiliary complications. Despite successful control measures, ongoing transmission persists due to environmental and social factors.

Background

Schistosomiasis is a neglected tropical disease affecting millions globally, particularly in tropical and subtropical regions. In Egypt, the disease has been endemic since ancient times, with significant morbidity linked to S. mansoni infections. Understanding the current epidemiology and clinical manifestations is crucial for effective management and prevention strategies.

Data Highlights

This study involved 130 symptomatic patients undergoing colonoscopy, focusing on the frequency of colonic schistosomiasis through rectal biopsy examination.

Key Findings

  • Schistosomiasis is endemic in Egypt, with S. mansoni being the dominant species.
  • Clinical manifestations include diarrhea, rectal bleeding, and abdominal pain due to chronic intestinal inflammation.
  • Rectal biopsy examination offers higher sensitivity for diagnosing schistosomiasis compared to serological tests.
  • Mass chemotherapy campaigns have reduced disease prevalence from 3% in 2003 to 0.3% in 2012.
  • Ongoing transmission is influenced by environmental factors such as poor sanitation and the presence of snail hosts.

Clinical Implications

Healthcare providers should be aware of the persistent risk of schistosomiasis in endemic regions and consider rectal biopsy for accurate diagnosis in symptomatic patients. Continued public health efforts are essential to address the underlying factors contributing to transmission.

Conclusion

Schistosomiasis remains a critical health issue in Egypt, necessitating ongoing surveillance and innovative control strategies to mitigate its impact on affected populations.

References

  1. WHO, NCBI Bookshelf, 2022 -- Summary of recommendations - WHO guideline on control and elimination of human schistosomiasis
  2. Italian Society of Tropical Medicine, Infection, 2023 -- Guidelines for Screening, Diagnosis, and Management of Schistosomiasis in Non-Endemic Regions
  3. Open Forum Infectious Diseases, 2023 -- Female Genital Schistosomiasis in Nonendemic Regions: A Retrospective Review
  4. Infection, 2020 -- Hematological Alterations Associated with Schistosoma haematobium Infections in Gabonese Schoolchildren
  5. Open Forum Infectious Diseases, 2023 -- Urogenital Schistosomiasis Presenting as IgG4-Related Disease in an HIV-Positive Patient
  6. ScienceDirect, 2025 -- Safety and efficacy of praziquantel 40 mg/kg versus 80 mg/kg in preschool-aged children with intestinal schistosomiasis in Uganda
  7. Summary of recommendations - WHO guideline on control and elimination of human schistosomiasis - NCBI Bookshelf
  8. Safety and efficacy of praziquantel 40 mg/kg versus 80 mg/kg in preschool-aged children with intestinal schistosomiasis in Uganda: a 2 × 2 factorial, double-blind, placebo-controlled, phase 2 randomised trial - ScienceDirect
  9. The impact and cost of a new rapid diagnostic test for school-based prevalence mapping and monitoring and evaluation surveys of schistosomiasis: A modelling study | PLOS Neglected Tropical Diseases

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