Effects of the active parts of Yangxin Tongmai Formula on myocardial injury and spatial metabolic remodeling in rats with myocardial ischemia-reperfusion injury - Report - MDSpire

Impact of Yangxin Tongmai Formula's Active Components on Myocardial Damage and Spatial Metabolic Changes in Rats Experiencing Ischemia-Reperfusion Injury

  • By

  • Di Ye

  • Yi Wang

  • Ziyuan Zhao

  • Caiyue Lin

  • Wenhua Xu

  • Jinghui Zheng

  • July 20, 2026

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Impact of Yangxin Tongmai Formula's Active Components on Myocardial Damage

Overview

The study investigates the protective effects of the active components of Yangxin Tongmai Formula (apr-YTF) against myocardial ischemia-reperfusion injury (MIRI) in rats.

Background

Myocardial ischemia-reperfusion injury (MIRI) is a significant complication following revascularization procedures for acute myocardial infarction, impacting patient prognosis. Current pharmacological interventions for MIRI are limited, necessitating exploration of alternative therapies. Traditional Chinese medicine, particularly formulations like Yangxin Tongmai, may offer novel cardioprotective strategies.

Data Highlights

ParameterControlModelVehicleapr-YTF
Left Ventricular Ejection Fraction (LVEF)------Significantly improved
Left Ventricular Fractional Shortening (LVFS)------Significantly improved
Serum CK Levels------Reduced
Infarct Size------Decreased
Metabolites Identified------1,282

Key Findings

  • apr-YTF improved left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS).
  • Reduction in serum myocardial enzyme levels (CK, CK-MB, LDH, LDH1) was observed.
  • Infarct size decreased following apr-YTF treatment.
  • MALDI-MSI identified 1,282 metabolites, with 702 associated with MIRI.
  • 17 differential metabolic features showed recovery trends post-apr-YTF intervention.

Clinical Implications

The findings suggest that apr-YTF may serve as a potential adjunctive therapy for myocardial ischemia-reperfusion injury. Further studies are warranted to explore its clinical applicability and mechanisms of action.

Conclusion

The active components of Yangxin Tongmai Formula demonstrate protective effects against myocardial injury.

Related Resources & Content

  1. Frontiers in Immunology, 2026 -- Hoxb4 upregulation by Xuan Bi Tong Yu Fang confers cardioprotection via repression of the Wnt/β-catenin pathway in myocardial ischemia-reperfusion injury
  2. Frontiers in Cardiovascular Medicine, 2026 -- Efficacy and safety of Shenqi Yangxin formula in patients with stable coronary artery disease based on CCTA: rationale, design, and study protocol for a randomized, double-blind, placebo-controlled study
  3. Frontiers in Immunology, 2026 -- Guanxinjing ameliorates coronary microvascular dysfunction in myocardial ischemia-reperfusion injury by alleviating inflammation and restoring endothelial function
  4. Basic Research in Cardiology, 2025 -- Triiodothyronine Mitigates Myocardial Injury by Decreasing Apoptosis and Supporting Mitochondrial Function
  5. JACC, 2025 -- 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes
  6. PMC, 2025 -- Intracoronary Vasoactive Therapy for No-Reflow During Primary PCI: A Network Meta-Analysis of Randomized Trials
  7. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | JACC
  8. Intracoronary Vasoactive Therapy for No-Reflow During Primary PCI: A Network Meta-Analysis of Randomized Trials - PMC

Original Source(s)

Effects of the active parts of Yangxin Tongmai Formula on myocardial injury and spatial metabolic remodeling in rats with myocardial ischemia-reperfusion injury

  • by Di Ye, Yi Wang, Ziyuan Zhao, Caiyue Lin, Wenhua Xu, Jinghui Zheng

  • July 20, 2026

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