Large Language Models in Colorectal Cancer Care and Clinical Decision Support: Systematic Review - Report - MDSpire

Large Language Models in Colorectal Cancer Care and Clinical Decision Support: Systematic Review

  • By

  • Jinglei Tian

  • Qifeng Lou

  • Xue Wang

  • Hangying Xu

  • Huiting Mei

  • Yanli Yu

  • May 21, 2026

  • 0 min

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Clinical Report: Systematic Review of Large Language Models in CRC Management

Overview

This systematic review evaluates the role of large language models (LLMs) in supporting clinical decisions for colorectal cancer (CRC) management.

Background

Colorectal cancer is a significant global health concern, being the third most commonly diagnosed cancer and a leading cause of cancer-related deaths.

Data Highlights

No specific numerical data or trial results were provided in the source material.

Key Findings

['LLMs can automate the extraction and processing of clinical records.', 'GPT-4 has shown promise in risk-stratified counseling and preoperative consultations for CRC.', 'LLMs have been utilized to generate colonoscopy reports and extract critical pathology data.', 'There is variability in the performance of different LLMs based on model selection and prompting strategies.', 'Challenges include inaccuracies, quality assurance concerns, and model bias.']

Clinical Implications

Healthcare professionals should recognize the limitations and variability in LLM performance.

Conclusion

The integration of LLMs in CRC management presents both opportunities and challenges.

Related Resources & Content

  1. ASCO Post, The ASCO Post, 2026 -- Large Language Models May Generate Concise, Coherent Pathology Summaries, Reducing Physician Burden
  2. ASCO Post, The ASCO Post, 2025 -- ESMO Publishes Guidance on Large Language Model Use for Oncology Practice
  3. npj Digital Medicine, npj Digital Medicine, 2026 -- Collaboration Between Humans and Large Language Models in Clinical Practice: A Systematic Review and Meta-Analysis
  4. npj Digital Medicine, npj Digital Medicine, 2026 -- CancerLLM: a large language model in cancer domain
  5. Recommendation: Colorectal Cancer: Screening | United States Preventive Services Taskforce
  6. Management of Locally Advanced Rectal Cancer: ASCO Guideline | Journal of Clinical Oncology
  7. Recommendation: Colorectal Cancer: Screening | United States Preventive Services Taskforce
  8. Management of Locally Advanced Rectal Cancer: ASCO Guideline | Journal of Clinical Oncology
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