Initial Presentation of Systemic Diffuse Large B-Cell Lymphoma as a Painful Penile Mass: A Case Study
By
Min-Jung Jan
Chia Hao Liang
Ming-Che Ou
Tang-Yi Tsao
Yi-Sheng Lin
Yen-Chuan Ou
Min-Che Tung
Chao-Yu Hsu
August 17, 2026
Clinical Scorecard: Initial Presentation of Systemic Diffuse Large B-Cell Lymphoma as a Painful Penile Mass: A Case Study
At a Glance
Category Detail
Condition Diffuse Large B-Cell Lymphoma (DLBCL) Key Mechanisms Extranodal malignancy with double expression of MYC and BCL-2 Target Population Adults, specifically a 58-year-old male in this case Care Setting Outpatient clinic and imaging facilities
Key Highlights
Rare presentation of DLBCL as a painful penile mass Confirmed diagnosis through ultrasound-guided core biopsy Significant metabolic activity detected via FDG PET/CT Treatment with R-CHOP systemic chemo-immunotherapy Achieved complete metabolic remission on follow-up imaging Guideline-Based Recommendations
Diagnosis
Histopathological confirmation via biopsy Use of FDG PET/CT for staging and identifying extranodal involvement Management
Systemic chemotherapy (R-CHOP) for treatment Preservation of organ function as a treatment goal Monitoring & Follow-up
Follow-up FDG PET/CT to assess treatment response Risks
Delayed diagnosis due to misidentification as other conditions Patient & Prescribing Data
Adult males with penile masses
Curative-intent systemic chemotherapy is preferred over surgical methods
Clinical Best Practices
Consider DLBCL in differential diagnosis of penile masses Utilize imaging and biopsy for accurate diagnosis and staging Monitor for potential extranodal involvement in lymphoma cases Related Resources & Content
